Pancreas-specific protein (PASP), serum amyloid A (SAA), and neopterin (NEOP) in the diagnosis of rejection after simultaneous pancreas and kidney transplantation

Transplant International : Official Journal of the European Society for Organ Transplantation
T F MüllerH Lange

Abstract

A reliable, noninvasive indicator of pancreatic allograft rejection is urgently needed. In this study, serum (S), plasma (P), and urine (U) levels of pancreas-specific protein (P-PASP, U-PASP), neopterin (S-NEOP, U-NEOP), amylase (U-AMYL), and amyloid A (SAA) were measured daily in ten type I diabetic patients following simultaneous pancreas and kidney transplantation (SPK). Rejection episodes occurred in three isolated pancreas, nine isolated kidney, and five simultaneous pancreas and kidney transplants. In the case of the eight pancreas rejections, SAA was the rejection marker with the highest diagnostic accuracy (94%). Using P-PASP and U-PASP, an accuracy of 81% and 79%, respectively, was achieved. During viral infections, U-NEOP levels increased to a maximum level of 1904 mumol/mol creatinine, whereas during bacterial infections, SAA levels increased to a maximum value of 43 mg/dl. SAA, measured for the first time in SPK, appears to be a valuable rejection parameter. In combination with U-NEOP and U-AMYL, a differential diagnosis between rejection, bacterial infection, and viral infection was possible. Neither U-PASP nor P-PASP monitoring led to a significant improvement in the results.

References

Jul 1, 1992·Transplant International : Official Journal of the European Society for Organ Transplantation·K KubotaC G Groth
Jan 1, 1989·Diabetes·C BrattströmC G Groth
Jan 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·R FernstadA Pousette
Jan 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·R J PloegF O Belzer

❮ Previous
Next ❯

Citations

Nov 6, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·H G SchneiderT Kotsimbos
Dec 20, 2000·Transplantation Proceedings·Y FukudaM Kanbe
Feb 24, 2001·Alzheimer Disease and Associated Disorders·M HullP S Aisen
Jun 9, 1998·Current Opinion in Nephrology and Hypertension·D E Sutherland
Dec 8, 2010·Proteomics. Clinical Applications·Baharak Vafadar-IsfahaniBalwir Matharoo-Ball
Dec 31, 2008·World Journal of Gastroenterology : WJG·Shamaila WaseemPeter V Draganov
Dec 24, 2004·Srpski arhiv za celokupno lekarstvo·Dijana B Jovanović

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.