Pancreas transplantation for diabetes mellitus

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
J D PirschM R Weir

Abstract

Pancreas transplantation has become a viable option for the patient wi th insulin-dependent diabetes mellitus with progressive renal failure. The most common type of pancreas transplantation is a simultaneous pancreas and kidney transplantation performed from a single cadaver donor (SPK). The next most common is pancreas transplantation after successful kidney transplantation (PAK). A few centers are performing pancreas transplantation alone (PTA) in diabetic recipients without renal disease but who have significant complications from their diabetes. Pancreas transplantation is associated with a higher morbidity than kidney transplantation alone. Most pancreas transplantation centers report a significant increase in acute rejection, which can lead to increased hospitalization and risk of opportunistic infection. In addition, the early era of pancreas transplantation was associated with significant surgical complications. However, with bladder drainage of the pancreas exocrine secretions, the surgical complication rate has decreased significantly. Despite medical and surgical complications, the overall results for pancreas transplantation are excellent, with 1 -year graft survival of 75% for SPK transplantations and 48% for PAK ...Continue Reading

Citations

Jan 1, 2011·Case Reports in Obstetrics and Gynecology·A SmythF Dunne
Apr 28, 2006·Clinical Transplantation·Pieter van de LindeAlexander F M Schaapherder
Jan 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ajay K IsraniKevin C Mange
Mar 26, 2002·Journal of the American Society of Nephrology : JASN·Sundaram HariharanRobert J Stratta
Oct 25, 2001·Journal of the American Society of Nephrology : JASN·Bryan N BeckerHans W Sollinger
Sep 1, 1996·Current Problems in Surgery·R J StrattaI S Gill
Dec 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R J StrattaI S Gill

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