Pancreatectomy with Mesenteric and Portal Vein Resection for Borderline Resectable Pancreatic Cancer: Multicenter Study of 406 Patients

Annals of Surgical Oncology
G RamacciatoUgo Boggi

Abstract

The role of pancreatectomy with en bloc venous resection and the prognostic impact of pathological venous invasion are still debated. The authors analyzed perioperative, survival results, and prognostic factors of pancreatectomy with en bloc portal (PV) or superior mesenteric vein (SMV) resection for borderline resectable pancreatic carcinoma, focusing on predictive factors of histological venous invasion and its prognostic role. A multicenter database of 406 patients submitted to pancreatectomy with en bloc SMV and/or PV resection for pancreatic adenocarcinoma was analyzed retrospectively. Univariate and multivariate analysis of factors related to histological venous invasion were performed using logistic regression model. Prognostic factors were analyzed with log-rank test and multivariate proportional hazard regression analysis. Complications occurred in 51.9 % of patients and postoperative death in 7.1 %. Histological invasion of the resected vein was confirmed in 56.7 % of specimens. Five-year survival was 24.4 % with median survival of 24 months. Vein invasion at preoperative computed tomography (CT), N status, number of metastatic lymph nodes, preoperative serum albumin were related to pathological venous invasion at uni...Continue Reading

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Citations

Aug 25, 2016·Langenbeck's Archives of Surgery·Emanuele F KauffmannUgo Boggi
Oct 5, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Niccolo' PetruccianiGiovanni Ramacciato
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Sep 18, 2018·European Journal of Gastroenterology & Hepatology·David MartinMarkus Schäfer
Feb 6, 2020·Archives of Pathology & Laboratory Medicine·Teddy Sutardji NagariaHuamin Wang
Nov 25, 2016·Annals of Surgical Oncology·Gyulnara G KasumovaJennifer F Tseng
Jul 14, 2017·Journal of Surgical Case Reports·Enio Campos AmicoRogério Lacerda Sousa
Jan 26, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Stefano CrippaMassimo Falconi
May 20, 2021·Updates in Surgery·Emanuele F KauffmannUgo Boggi
Nov 9, 2021·Future Oncology·Monish Karunakaran, Savio George Barreto

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