Pancreatic β-cell regeneration: advances in understanding the genes and signaling pathways involved

Genome Medicine
Solomon Afelik, Meritxell Rovira

Abstract

Recent advances in β-cell regeneration in vivo are providing insights into the mechanisms involved in the conversion of distinct pancreatic cell lineages into β cells. These mechanisms mostly involve reactivation of the gene encoding the pancreatic endocrine cell-specifying transcription factor neurogenin-3.

References

Jan 7, 2016·Proceedings of the National Academy of Sciences of the United States of America·Mingfeng ZhangDefu Zeng
Oct 4, 2016·The Journal of Clinical Investigation·Jacqueline R BenthuysenMaike Sander
Nov 14, 2016·Molecular and Cellular Endocrinology·Solomon Afelik, Meritxell Rovira
May 17, 2017·Diabetes·Jeffrey R Millman, Felicia W Pagliuca

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Citations

May 14, 2019·Journal of Cellular Biochemistry·Roozbeh Akbari MotlaghSeyed Mohammad Gheibi Hayat

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Methods Mentioned

BETA
genetic modifications
transgenic
genetic modification

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