Pancreatic acinar atrophy in German shepherd dogs and rough-coated collies. Etiopathogenesis, diagnosis and treatment. A review

The Veterinary Quarterly
Maria E Wiberg

Abstract

In pancreatic acinar atrophy (PAA) a selective destruction of digestive enzyme-producing acinar cells leads to maldigestion signs typical of exocrine pancreatic insufficiency (EPI). Although the clinical disease is well-known, the etiopathogenesis of PAA has been long remained obscure. German shepherd dogs and rough-coated Collies with PAA show similar genetic, clinical and pathological findings indicating a similar etiopathogenesis of the disease in these two breeds. In this review article the etiopathogenesis of PAA is discussed, including the current suggestion of autoimmune nature of the disease. The diagnostic methods for detection both early and end-stage exocrine pancreatic dysfunction are described, as well as the treatment options and prognosis.

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Citations

Nov 23, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Kate L TsaiLeigh Anne Clark
Jan 30, 2009·Journal of Veterinary Internal Medicine·K BrennerG Kennedy
Nov 15, 2012·Topics in Companion Animal Medicine·Elias Westermarck, Maria Wiberg
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Jan 24, 2006·Journal of the American Veterinary Medical Association·Elias Westermarck, Maria E Wiberg
Nov 5, 2015·Journal of the American Animal Hospital Association·Maria Saiz AlvarezJorge Martínez

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