PMID: 9422322Jan 9, 1998Paper

Pancreatic acinar cell clusters in pediatric gastric mucosa

The American Journal of Surgical Pathology
S KrishnamurthyY Dayal

Abstract

Although clusters of pancreatic acinar cells (CPACs) have been reported in gastric mucosa of adults, they have not been described in children. We reviewed 283 pediatric gastric (239 antral and 44 corpus) mucosal biopsies during a 2-year period and detected CPACs in 10 antral biopsy samples. These biopsy samples were stained immunohistochemically for pancreatic exocrine markers (trypsin, chymotrypsin, alpha-amylase, and lipase) and a panel of regulatory substances (insulin, glucagon, somatostatin, pancreatic polypeptide, gastrin, and serotonin). Double immunostaining for colocalization of chromogranins and trypsin as well as mucin and trypsin also were performed on all cases. CPACs were seen in antral mucosa in a background of either normal or minimally inflamed mucosa, without any atrophy or metaplasia, and were positive for all pancreatic exocrine markers. Stray chromogranin-positive cells in the CPACs were also immunopositive for somatostatin, gastrin, or serotonin. All CPACs showed a few hybrid (amphicrine) cells that coexpressed both chromogranin and trypsin. In one case, ultrastructural examination showed such cells to contain both zymogen and neurosecretory granules. Although the presence of CPACs exclusively in the antru...Continue Reading

References

Apr 29, 1977·Virchows Archiv. A, Pathological Anatomy and Histology·C CapellaP Fontana
Mar 1, 1974·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·C CavalleroM Cavallero
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Oct 1, 1995·The American Journal of Surgical Pathology·S Krishnamurthy, Y Dayal
Dec 1, 1996·The American Journal of Surgical Pathology·H H WangD A Antonioli

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Citations

Aug 26, 2011·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Arthur G Weinberg
Mar 10, 2000·The American Journal of Gastroenterology·W PolkowskiG J Offerhaus
Feb 19, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Michael TorbensonTsung-Teh Wu
Jun 26, 2003·Archives of Pathology & Laboratory Medicine·Nirag C JhalaJuan Lechago

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