Pancreatic acinar cell: new insights into the control of secretion

The International Journal of Biochemistry & Cell Biology
Jiun T LowPeter Thorn

Abstract

Pancreatic acinar cells secrete fluid and digestive enzymes. Both types of secretion are activated by a rise in intracellular calcium but how the stimulus-secretion cascade actually regulates secretory output is not well understood. It has long been known that the calcium response of acinar cells to physiological stimulation is complex. Dependent on the type and concentration of agonist, it consists of either local or global calcium increases as well as spreading waves of calcium across the cell. In the past it has been speculated that these different calcium signals drive different secretory responses. Now, recent employment of two-photon microscopy has enabled the simultaneous recording of both enzyme secretion and calcium signals and is beginning to resolve this issue. The data shows that local calcium responses exclusively drive fluid secretion. Where-as, global calcium responses drive both fluid and enzyme secretion. This differential control of secretory output is likely central to controlling the physiological responses of pancreatic acinar cells.

References

Jun 9, 2000·Annual Review of Physiology·J F Kidd, P Thorn
Mar 7, 2001·Nature Cell Biology·T NemotoH Kasai
Apr 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Peter ThornIan Parker
Jul 8, 2005·American Journal of Physiology. Cell Physiology·Ying ChenDavid R Giovannucci
Jun 29, 2007·Molecular Biology of the Cell·Olga LarinaPeter Thorn
Apr 22, 2009·Gastroenterology·Herbert Y Gaisano, Fred S Gorelick
Jan 12, 2010·Annual Review of Medicine·David C Whitcomb
Aug 26, 2010·Journal of Cell Science·Jiun T LowPeter Thorn

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Citations

Jul 12, 2014·Journal of Bioenergetics and Biomembranes·Neeraj Manhas, K R Pardasani
Apr 10, 2016·Journal of Digestive Diseases·Jian Sheng WuQin Fen Chen
Nov 13, 2019·Journal of Morphology·Magdalena Kowalska, Weronika Rupik
Dec 5, 2014·World Journal of Gastroenterology : WJG·Jun LiZong-Fang Li
Oct 14, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Hiromitsu MaehiraMasaji Tani

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