Pancreatic acinar cells: molecular insight from studies of signal-transduction using transgenic animals.

The International Journal of Biochemistry & Cell Biology
D I Yule

Abstract

Pancreatic acinar cells are classical exocrine gland cells. The apical regions of clusters of coupled acinar cells collectively form a lumen which constitutes the blind end of a tube created by ductal cells - a structure reminiscent of a "bunch of grapes". When activated by neural or hormonal secretagogues, pancreatic acinar cells are stimulated to secrete a variety of proteins. These proteins are predominately inactive digestive enzyme precursors called "zymogens". Acinar cell secretion is absolutely dependent on secretagogue-induced increases in intracellular free Ca(2+). The increase in [Ca(2+)](i) has precise temporal and spatial characteristics as a result of the exquisite regulation of the proteins responsible for Ca(2+) release, Ca(2+) influx and Ca(2+) clearance in the acinar cell. This brief review discusses recent studies in which transgenic animal models have been utilized to define in molecular detail the components of the Ca(2+) signaling machinery which contribute to these characteristics.

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Citations

Aug 2, 2013·Journal of Physiology and Biochemistry·Patricia Santofimia-CastañoAntonio González
Oct 18, 2012·Physiological Reviews·Haruo KasaiHiroshi Tokumaru
Jan 17, 2012·Traffic·Andrius MasedunskasRoberto Weigert

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