Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Aurelia LugeaStephen J Pandol

Abstract

The majority of those who drink excessive amounts of alcohol do not develop pancreatic disease. One overarching hypothesis is that alcohol abuse requires additional risk factors, either environmental or genetic, for disease to occur. However, another reason be a result of alcohol-induced activation of adaptive systems that protect the pancreas from the toxic effects of alcohol. We show that mechanisms within the unfolded protein response (UPR) of the endoplasmic reticulum (ER) that can lead to protection of the pancreas from pancreatic diseases with alcohol abuse. The remarkable ability of the pancreas to adapt its machinery to alcohol abuse using UPR systems and continue functioning is the likely reason that pancreatitis from alcohol abuse does not occur in the majority of heavy drinkers. These findings indicate that methods to enhance the protective responses of the UPR can provide opportunities for prevention and treatment of pancreatic diseases.

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Citations

May 14, 2016·Pancreas·Veronica Wendy SetiawanKristine R Monroe
Jul 19, 2016·Current Opinion in Gastroenterology·Anna S GukovskayaIlya Gukovsky
Feb 26, 2016·World Journal of Gastrointestinal Pathophysiology·Dahn L ClemensShailender Singh
Nov 14, 2018·Biomolecular Concepts·Troy L Merry, Maxim S Petrov
Mar 13, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lindsey Phillipson-WeinerTracy G Anthony
Jul 7, 2017·Current Opinion in Gastroenterology·Bomi LeeAida Habtezion
Oct 5, 2018·World Journal of Gastrointestinal Pathophysiology·Kaylene BarreraChongmin Huan
May 16, 2017·Digestive Diseases and Sciences·Daniel LewStephen Pandol
Sep 10, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jiayue YangStephen J Pandol
Feb 3, 2018·International Journal of Molecular Medicine·Weiping Zhang, Jianming Xu
Mar 2, 2021·Journal of Hepato-biliary-pancreatic Sciences·Huaxun WuJia Luo

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Methods Mentioned

BETA
glycosylation
protein folding
protein

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