Pancreatic adenocarcinoma: the impact of preneoplastic lesion pattern on survival

Bioscience Trends
Yves FlattetNermin Halkic

Abstract

Pancreatic adenocarcinoma is associated with a very poor prognosis, characterized with a 5-year survival rate of only 5%. Surgery is the only curative treatment for selected patients. Nevertheless, recurrence is very frequent. Identifying prognostic factors is thus warranted. Like numerous other tumors, adenocarcinomas are preceded by preneoplastic lesions. The role and the impact of these lesions remain unclear. This study aimed to assess the impact of the preneoplastic lesion pattern and histo-morphological features, on survival after pancreatic resection. Thirty-five patients who underwent pancreatic resection for pancreatic adenocarcinoma were identified from a prospective database of a single center, between 2003 and 2008. We considered demographics, tumor characteristics and type of treatment. The major outcome was survival. Analyzes were separated into two groups, according to the preneoplastic lesions: Pancreatic intraepithelial neoplasia (PanIN)-related carcinomas and intracanalar papillary mucinous neoplasia (IPMN)-related carcinomas. The former were more frequent, accounting for 63% (22/35). Moreover, they displayed more aggressive features, with a higher tumor stage (p = 0.01) and higher rate of positive lymph nodes...Continue Reading

References

Oct 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Aleodor AndeaVolkan N Adsay
Apr 4, 2007·The American Journal of Gastroenterology·Yasser ShaibHashem El-Serag
Apr 24, 2007·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Mansher Singh, Anirban Maitra
May 24, 2007·Journal of Hepato-biliary-pancreatic Surgery·Kyoichi Takaori
May 24, 2007·Journal of Hepato-biliary-pancreatic Surgery·Kohji NagataSuguru Yonezawa
Sep 28, 2007·Virchows Archiv : an International Journal of Pathology·Snezana Andrejevic-BlantGünter Klöppel
Dec 17, 2008·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·B SiposG Klöppel
Sep 30, 2009·Journal of Hepato-biliary-pancreatic Sciences·Suguru YonezawaMasamichi Goto
Apr 30, 2010·The New England Journal of Medicine·Manuel Hidalgo
Jul 3, 2013·Best Practice & Research. Clinical Gastroenterology·Giuseppe ZamboniAnne Marie Lennon
Nov 19, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Niloufar DuschMarco Niedergethmann
Apr 26, 2014·Pancreas·Takashi KokudoNermin Halkic

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Citations

Sep 14, 2016·World Journal of Gastroenterology : WJG·Yu-Hua ZhangDe-Fei Hong

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