Abstract
Pancreatic adenocarcinoma upregulated factor (PAUF), a novel oncogene, plays a crucial role in the development of pancreatic cancer, including its metastasis and proliferation. Therefore, PAUF-expressing pancreatic cancer cells could be important targets for oncolytic virus-mediated treatment. Panc-1 cells expressing PAUF (Panc-PAUF) showed relative resistance to parvovirus H-1 infection compared with Panc-1 cells expressing an empty vector (Panc-Vec). Of interest, expression of type I IFN-α receptor (IFNAR) was higher in Panc-PAUF cells than in Panc-Vec cells. Increased expression of IFNAR in turn increased the activation of Stat1 and Tyk2 in Panc-PAUF cells compared with that in Panc-Vec cells. Suppression of Tyk2 and Stat1, which are important downstream molecules for IFN-α signaling, sensitized pancreatic cancer cells to parvovirus H-1-mediated apoptosis. Further, constitutive suppression of PAUF sensitized Bxpc3 pancreatic cancer cells to parvovirus H-1 infection. Taken together, these results suggested that PAUF conferred resistance to pancreatic cancer cells against oncolytic parvovirus H-1 infection through IFNAR-mediated signaling.
References
Oct 6, 1998·Annual Review of Biochemistry·G R StarkR D Schreiber
Oct 20, 1999·Cellular and Molecular Life Sciences : CMLS·T C Yeh, S Pellegrini
Jan 30, 2003·The EMBO Journal·Josiane RagimbeauSandra Pellegrini
Feb 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nikolai N KhodarevRalph R Weichselbaum
Apr 6, 2006·Cancer Research·Michael G KellyGil Mor
Oct 10, 2006·Virology·Il-Rae ChoYoung-Hwa Chung
Oct 31, 2006·International Journal of Cancer. Journal International Du Cancer·Mårten FryknäsAnders Isaksson
Feb 9, 2007·Journal of Virology·Matteo Di PiazzaJean Rommelaere
Oct 9, 2007·Biochemical and Biophysical Research Communications·Hisamitsu IdeShigeo Horie
Nov 24, 2007·Drugs·Paula GhanehJohn P Neoptolemos
Nov 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ralph R WeichselbaumAndy J Minn
Mar 24, 2009·Cancer Science·Sun A KimSi Young Song
Sep 29, 2009·Oncogene·Y LeeS S Koh
Oct 27, 2009·International Journal of Cancer. Journal International Du Cancer·Sebastian DempeChristiane Dinsart
Dec 24, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Béatrice Payelle-Brogard, Sandra Pellegrini
Aug 31, 2010·Oncogene·H D ParkD-S Lim
Feb 19, 2011·Future Virology·Aaron Yun Chen, Jianming Qiu
Jul 1, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Irina KiprianovaJörg R Schlehofer
Oct 26, 2011·Cancer Biology & Therapy·Svitlana P GrekovaZahari Raykov
Mar 23, 2012·BMC Cancer·Karsten GeletnekyJacek Hajda
Nov 30, 2012·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Sujata HalderMavis Agbandje-McKenna
Aug 7, 2013·International Journal of Oncology·Waraporn MalilasYoung-Hwa Chung