Pancreatic and pulmonary mast cells activation during experimental acute pancreatitis.

World Journal of Gastroenterology : WJG
Inmaculada Lopez-FontDaniel Closa

Abstract

To study the activation of pancreatic and pulmonary mast cells and the effect of mast cell inhibition on the activation of peritoneal and alveolar macrophages during acute pancreatitis. Pancreatitis was induced by intraductal infusion of 5% sodium taurodeoxycholate in rats. The mast cell inhibitor cromolyn was administered intraperitoneally (i.p.) 30 min before pancreatitis induction. The pancreatic and pulmonary tissue damage was evaluated histologically and mast cells and their state of activation were evaluated. Peritoneal and alveolar macrophages were obtained and the expression of tumor necrosis factor alpha was determined. Myeloperoxidase activity was measured to evaluate the effect of mast cell inhibition on the progression of the inflammatory process. Finally, the effect of plasma on cultured mast cells or macrophages was evaluated in vitro. The mast cell stabilizer significantly reduced inflammation in the pancreas and lung and the activation of alveolar macrophages but had no effect on peritoneal macrophages. Mast cell degranulation was observed in the pancreas during pancreatitis but no changes were observed in the lung. Plasma from rats with pancreatitis could activate alveolar macrophages but did not induce degranu...Continue Reading

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Citations

Nov 14, 2015·Expert Opinion on Therapeutic Targets·Muhammad ShamoonJia Sun
Apr 11, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Alison S F ElderDani-Louise Dixon
Jul 4, 2012·Respiratory Medicine·Hamid AkbarshahiRoland Andersson
Apr 5, 2013·Toxicology and Industrial Health·Yildiray KalkanAlparslan Turan
Aug 30, 2014·World Journal of Gastroenterology : WJG·Kristin S InmanNicole R Murray
Aug 23, 2019·International Journal of Molecular Medicine·Dong-Uk KimSung-Joo Park
Feb 13, 2018·Immunological Reviews·Barbara FrossiCarlo E M Pucillo
Apr 24, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Hemanth K KandikattuAnil Mishra

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