PMID: 7013399Jul 1, 1980Paper

Pancreatic B-cell response to a test-meal in lean and obese diabetic patients: relation to metabolic control

Acta diabetologica latina
J C DaubresseP J Lefebvre

Abstract

We have measured fasting C-peptide reactivity (CPR) as well as CPR responses to a test meal in 83 diabetic patients and 41 non diabetic controls. In comparison to controls, basal CPR was decreased in lean insulin-treated diabetics with stable or brittle diabetes and in obese patients with brittle diabetes. Lean and obese maturity-onset diabetics had increased CPR levels and so had obese insulin-treated patients. Nevertheless, the CPR response to the test meal was clearly inadequate in all diabetics. In control patients, there was a positive correlation between fasting blood glucose and CPR levels. On the contrary, lean diabetics demonstrated a negative correlation between these parameters. Hemoglobin A1 levels were negatively correlated to fasting CPR levels in lean diabetics, indicating the importance of residual B-cell function for diabetes control. These correlations were obscured in obese diabetics. In our patients, circulating insulin antibodies had apparently no deleterious effect on metabolic control.

References

Jan 1, 1978·Metabolism: Clinical and Experimental·D K YueJ R Turtle
Mar 1, 1978·Archives of Internal Medicine·A Lev-Ran
Dec 1, 1976·The Journal of Clinical Endocrinology and Metabolism·R H MortimerR G Freeman
Jun 1, 1975·The Journal of Clinical Investigation·D L HorwitzA H Rubenstein
Nov 1, 1974·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G FinkL Recant
Sep 1, 1972·The Journal of Clinical Endocrinology and Metabolism·M B BlockA H Rubenstein
May 1, 1970·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A H Christiansen

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