Pancreatic beta cells: responding to the matrix

Cell Metabolism
Kenneth S Zaret

Abstract

In a recent issue of Developmental Cell, Nikolova et al. (2006) make the unusual discovery that, unlike most epithelial cells, pancreatic beta cells do not produce a basement membrane of extracellular matrix. Rather, the matrix is provided to a subset of beta cells by local capillary endothelial cells, explaining in part how the endothelium helps promote optimal levels of insulin production.

References

Jul 11, 2002·Diabetologia·L Jansson, P-O Carlsson
Sep 17, 2002·Current Opinion in Cell Biology·Edna CukiermanKenneth M Yamada

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Citations

Jul 27, 2012·Development·Ondine Cleaver, Yuval Dor
Jul 19, 2012·PloS One·Keren Kaufman-FrancisShulamit Levenberg
Aug 19, 2010·Journal of Tissue Engineering and Regenerative Medicine·Ipsita BanerjeeMartin Yarmush
Apr 22, 2014·Molecular Metabolism·Adriana MiglioriniHeiko Lickert
Nov 4, 2016·Nature Reviews. Endocrinology·Sara S RoscioniHeiko Lickert
Oct 8, 2009·Cell Metabolism·Zvi GranotYuval Dor
Oct 4, 2011·Development·Judith MagenheimYuval Dor
Feb 6, 2008·Cell Metabolism·Gaëlle LaurentFatima Mechta-Grigoriou

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