Pancreatic cancer and obesity: epidemiology, mechanism, and preventive strategies

Clinical Journal of Gastroenterology
Prashanth RawlaTagore Sunkara

Abstract

The prevalence of obesity has seen a global increase in the past decades, escalating to one of the major epidemiological challenges today. Global economic growth has caused changes in dietary and physical activity patterns fueling obesity across age, gender, and income groups. The implications are many, as obesity has been associated with numerous serious health conditions, ultimately affecting morbidity and mortality. There is a growing recognition of the risk a high body mass index confers on the development and outcome of several malignancies, including pancreatic cancer. Pancreatic cancer is a highly lethal disease with exceptionally poor outcome, with incidences rising worldwide. Due to vague symptoms and no screening recommendations, a vast majority of patients are diagnosed at late stages, with already advanced disease and no opportunity for surgical intervention. Obesity mediates risk for pancreatic cancer through insufficiently understood mechanisms, possibly including inflammation and hormonal misbalance. As excess abdominal adiposity is among the few modifiable risk factors for pancreatic cancer onset, enduring weight loss could manifest an effective preventive measure. Lifestyle modifications on a population level a...Continue Reading

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Sep 30, 2019·European Journal of Epidemiology·Sabine NaudinPietro Ferrari
Sep 13, 2019·Journal of Clinical Medicine·Hui-Jen Tsai, Jeffrey S Chang
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Dec 3, 2020·Cancer Letters·Weiqin LuYongde Luo
Aug 10, 2021·World Journal of Gastroenterology : WJG·Jian-Xiong HuFeng Gao

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