Pancreatic Cancer Metabolism: Molecular Mechanisms and Clinical Applications.

Current Oncology Reports
Abdel Nasser Hosein, Muhammad Shaalan Beg

Abstract

Pancreatic adenocarcinoma is a leading cause of cancer mortality in western countries with a uniformly poor prognosis. Unfortunately, there has been little in the way of novel therapeutics for this malignancy over the last several decades. Derangements in metabolic circuitry favoring excess glycolysis are increasingly recognized as a key hallmark of cancer. The role of alterations in glutamine metabolism in pancreatic tumor progression has been elucidated in animal models and human cells lines, and there has been considerable interest in exploiting these aberrations for the treatment of pancreatic cancer. Other strategies targeting NQO1/GLS1 inhibition, NAD+ synthesis, and TCA cycle intermediates are being actively studied in the clinic. Aberrant metabolism in pancreatic cancer poses a unique therapeutic strategy. We review preclinical and clinical studies looking to exploit alterations in the metabolic circuitry of pancreatic cancer.

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Citations

Mar 2, 2019·Cell Communication and Signaling : CCS·Dan WangWeiqin Lu
Dec 2, 2020·Journal of Experimental & Clinical Cancer Research : CR·Lidong CaoRanji Cui
Apr 5, 2020·Chinese Journal of Natural Medicines·Xiao FuYu-Dong Qiu
Oct 12, 2021·Experimental Biology and Medicine·Qiangda ChenWenchuan Wu

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