Pancreatic cancer

Lancet
Terumi KamisawaKyoichi Takaori

Abstract

Pancreatic cancer is a highly lethal disease, for which mortality closely parallels incidence. Most patients with pancreatic cancer remain asymptomatic until the disease reaches an advanced stage. There is no standard programme for screening patients at high risk of pancreatic cancer (eg, those with a family history of pancreatic cancer and chronic pancreatitis). Most pancreatic cancers arise from microscopic non-invasive epithelial proliferations within the pancreatic ducts, referred to as pancreatic intraepithelial neoplasias. There are four major driver genes for pancreatic cancer: KRAS, CDKN2A, TP53, and SMAD4. KRAS mutation and alterations in CDKN2A are early events in pancreatic tumorigenesis. Endoscopic ultrasonography and endoscopic ultrasonography-guided fine-needle aspiration offer high diagnostic ability for pancreatic cancer. Surgical resection is regarded as the only potentially curative treatment, and adjuvant chemotherapy with gemcitabine or S-1, an oral fluoropyrimidine derivative, is given after surgery. FOLFIRINOX (fluorouracil, folinic acid [leucovorin], irinotecan, and oxaliplatin) and gemcitabine plus nanoparticle albumin-bound paclitaxel (nab-paclitaxel) are the treatments of choice for patients who are no...Continue Reading

References

Jun 11, 1987·The New England Journal of Medicine·F M GiardielloG D Luk
Nov 1, 1995·Pancreas·T KamisawaA Okamoto
Jul 1, 1996·Cancer·A M GattaniH W Bruckner
Mar 19, 1997·Journal of the National Cancer Institute·A B LowenfelsD C Whitcomb
Dec 8, 1998·JAMA : the Journal of the American Medical Association·C B BeggM F Brennan
Sep 19, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anirban MaitraRalph H Hruban
Mar 19, 2004·The New England Journal of Medicine·John P NeoptolemosUNKNOWN European Study Group for Pancreatic Cancer
Feb 9, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·X G NiP Zhao
Aug 10, 2005·Virchows Archiv : an International Journal of Pathology·Toru FurukawaSuguru Yonezawa
Nov 14, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K S Goonetilleke, A K Siriwardena
Feb 16, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Fergus J CouchRalph H Hruban
Apr 25, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Malcolm J MooreUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Jan 15, 2008·Langenbeck's Archives of Surgery·Simona IodiceAlbert B Lowenfels
Mar 25, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Florence HuguetDavid Azria
Apr 24, 2009·Annals of Surgical Oncology·Douglas B EvansRichard D Schulick
May 6, 2009·European Radiology·Sung Soo AhnJoon Seok Lim
Aug 19, 2009·Topics in Magnetic Resonance Imaging : TMRI·Numan Cem BalciMehmet Bilgin
Oct 29, 2009·JAMA : the Journal of the American Medical Association·Fay KastrinosSapna Syngal
Jun 1, 2010·Best Practice & Research. Clinical Gastroenterology·Sara RaimondiRaffaele Pezzilli
Oct 6, 2010·Advances in Surgery·Ralph H HrubanAlison P Klein
Dec 4, 2010·World Journal of Gastroenterology : WJG·Mario TestiniGiuseppe Piccinni
Mar 18, 2011·World Journal of Gastroenterology : WJG·Chakshu SharmaMichele Molinari
May 14, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Uwe PelzerHelmut Oettle
May 31, 2011·Lancet·Audrey VincentMichael Goggins
Jul 22, 2011·Science Translational Medicine·Jian WuBert Vogelstein
Aug 4, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-L Van LaethemM Lutz
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick J LoehrerAl B Benson
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip Agop Philip
Dec 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jian WuBert Vogelstein
Jan 10, 2012·Gastroenterology·Mitsuro KandaMichael Goggins
Jun 8, 2012·Journal of Surgical Oncology·Claudius Conrad, Carlos Fernández-Del Castillo
Jun 13, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Masao TanakaUNKNOWN International Association of Pancreatology
Jun 13, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Yaojun ZhangLong R Jiao
Jun 19, 2012·Gastrointestinal Endoscopy·Ting-ting GongQi Zhu
Nov 9, 2012·Gut·Marcia Irene CantoUNKNOWN International Cancer of Pancreas Screening (CAPS) Consortium

❮ Previous
Next ❯

Citations

Feb 27, 2016·Biochemical and Biophysical Research Communications·Wenhua LiLei Gong
Nov 3, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S BoeckV Heinemann
Jan 18, 2017·Cancer Letters·Naoki YoshidaTooru Shimosegawa
Jan 24, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mario UccelloHendrik-Tobias Arkenau
Mar 1, 2017·Journal of Proteome Research·Anna DrabikMarek Sierzega
May 24, 2017·International Journal of Molecular Sciences·Steffen OrmannsStefan Boeck
May 5, 2017·European Journal of Gastroenterology & Hepatology·Frédérique MairePhilippe Ruszniewski
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yin YinXuenong Ouyang
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sven H LoosenTom Luedde
Jan 31, 2018·Journal of Cell Communication and Signaling·Monica AasrumIngvild J Brusevold
Feb 13, 2018·Journal of Experimental & Clinical Cancer Research : CR·Chi FangLing Tian
Jan 11, 2018·Cancers·Alette RuarusMartijn Meijerink
Feb 10, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Emily A ArmstrongMary E Dillhoff
Apr 4, 2018·Cancers·Mizuho Sato-DahlmanMasato Yamamoto
Nov 18, 2017·International Journal of Epidemiology·Vanessa L Gordon-DseaguRachael Stolzenberg-Solomon
Jan 19, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Duck Mi YoonShin Hyung Kim
Sep 16, 2017·International Journal of Cancer. Journal International Du Cancer·Daniele CampaFederico Canzian
Aug 26, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Liang-He LuRong-Ping Guo
Feb 7, 2018·Current Pharmacology Reports·Amanda R MuñozAddanki P Kumar
Sep 21, 2017·Expert Opinion on Therapeutic Patents·Houria BoulaizJuan Antonio Marchal
Feb 22, 2017·World Journal of Gastrointestinal Pharmacology and Therapeutics·Gurshawn SinghZeeshan Ramzan
Jan 9, 2018·World Journal of Gastroenterology : WJG·Fan YangSi-Yu Sun
Mar 7, 2018·Journal of Surgical Oncology·Victor Hugo Fonseca de JesusFelipe José Fernandez Coimbra
Jun 22, 2018·The Cochrane Database of Systematic Reviews·Wei ZhangZuojin Liu
Jul 5, 2018·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Tatiana Falcão EyffAlessandro Bersch Osvaldt
Aug 15, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Linda D MellbyCarl A K Borrebaeck
Oct 24, 2017·Cell Proliferation·Fuyou ZhangWeiren Huang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Related Papers

The New England Journal of Medicine
Thierry ConroyPRODIGE Intergroup
The New England Journal of Medicine
Daniel D Von HoffMarkus F Renschler
The New England Journal of Medicine
Leonard B Saltz, Peter B Bach
The New England Journal of Medicine
Ranjit K Sahoo, Lalit Kumar
JAMA : the Journal of the American Medical Association
John P NeoptolemosEuropean Study Group for Pancreatic Cancer
© 2021 Meta ULC. All rights reserved