Jul 1, 2020

Pancreatic cancer

Lancet
Jonathan D MizrahiRachna T Shroff

Abstract

Pancreatic cancer is a highly fatal disease with a 5-year survival rate of approximately 10% in the USA, and it is becoming an increasingly common cause of cancer mortality. Risk factors for developing pancreatic cancer include family history, obesity, type 2 diabetes, and tobacco use. Patients typically present with advanced disease due to lack of or vague symptoms when the cancer is still localised. High quality computed tomography with intravenous contrast using a dual phase pancreatic protocol is typically the best method to detect a pancreatic tumour and to determine surgical resectability. Endoscopic ultrasound is an increasingly used complementary staging modality which also allows for diagnostic confirmation when combined with fine needle aspiration. Patients with pancreatic cancer are often divided into one of four categories based on extent of disease: resectable, borderline resectable, locally advanced, and metastatic; patient condition is also an important consideration. Surgical resection represents the only chance for cure, and advancements in adjuvant chemotherapy have improved long-term outcomes in these patients. Systemic chemotherapy combinations including FOLFIRINOX (5-fluorouracil, folinic acid [leucovorin],...Continue Reading

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Mentioned in this Paper

Endoscopic Ultrasound
Immunotherapy
Oxaliplatin
PARP1 protein, human
Leucovorin
Pancreatic Duct
Obesity
BRCA1
Family History
Fluorouracil/Irinotecan/Leucovorin Calcium/Oxaliplatin

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