PMID: 11328792May 1, 2001Paper

Pancreatic concentrations of cefepime

The Journal of Antimicrobial Chemotherapy
R DelcenserieJ L Dupas

Abstract

The concentrations of cefepime in pancreatic pseudocyst fluid (n = 4), pancreatic tissue (n = 4) and pancreatic fistula fluid (n = 1), and simultaneous plasma concentrations, were measured after intravenous administration of a single 2 g dose to nine patients. Mean plasma concentration was 27.4 mg/L between 120 and 200 min after the end of infusion. Mean pancreatic cefepime concentration was 6.3 mg/L in pseudocyst and 10.7 mg/L in pancreatic tissue. Cefepime was detected by 30 min after the end of the perfusion in pancreatic fistulae fluid, and persisted at 8 h. We conclude that cefepime is a potentially useful antibiotic in prevention and treatment of pancreatic infection.

References

Dec 1, 1992·Gastroenterology·M BüchlerH G Beger
Jan 1, 1987·Antimicrobial Agents and Chemotherapy·R H BarbhaiyaK A Pittman
Sep 9, 1995·Lancet·V SainioE Kivilaakso
Dec 1, 1996·The Annals of Pharmacotherapy·M A Wynd, J A Paladino
Jul 14, 1999·Gut·S W SchmidM W Büchler

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Citations

Jul 21, 2009·Gastroenterología y hepatología·Enrique de-Madaria, Juan F Martínez Sempere
Apr 8, 2003·Journal of Chemotherapy·D PapagorasH Giamarellou
Dec 5, 2008·Expert Review of Anti-infective Therapy·Andrea EndimianiRobert A Bonomo
Aug 6, 2009·Journal of Chemotherapy·T Mazzei, A Novelli

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