PMID: 9548683Apr 21, 1998Paper

Pancreatic diabetes in Japan

Pancreas
M KoizumiT Toyota

Abstract

Pancreatic diabetes is usually a complication of other pancreatic disorders. Diabetes was a complication in 55.5% of 2,774 patients with chronic pancreatitis (CP) in Japan. More than half of alcoholic patients with CP in our clinic showed diabetes, and approximately 50% of those patients with diabetes were treated with insulin injections. On the other hand, cases of nonalcoholic CP showed mild endocrine dysfunction in terms of diabetic frequency and severity. Epidemiologic studies suggest that diabetes resulting from chronic pancreatitis accounts for <0.8% of all Japanese patients with diabetes. In patients with CP, B-cell dysfunction occurred first, followed by disturbances in A-cell function. Decreased insulin secretion during postprandial periods plays an important role in pancreatic diabetes. The fasting level of blood glucose is not useful for the diagnosis of the early stage of pancreatic diabetes. The glucose-tolerance test should be performed to diagnose early-stage diabetes in patients with CP with normal fasting blood glucose levels. For control of blood glucose in diabetic patients with CP, multiple injections of short-acting effective insulin before the meal are necessary. The incidence of long-term diabetic complic...Continue Reading

Citations

Apr 28, 2007·Journal of Gastroenterology·Tetsuhide ItoUNKNOWN Research Committee of Intractable Diseases of the Pancreas
Jul 20, 2002·Diabetes Research and Clinical Practice·Makoto WatanabeSohel Reza Choudhury
Feb 26, 2010·Pancreas·Tetsuhide ItoUNKNOWN Research Committee of Intractable Diseases of the Pancreas
Feb 1, 2009·Clinical Journal of Gastroenterology·Ken KawabeRyoichi Takayanagi
Sep 8, 2011·Journal of Clinical Gastroenterology·Nancy ChenCapecomorin S Pitchumoni
Aug 8, 2006·Current Opinion in Gastroenterology·Matthew J DiMagno, Eugene P Dimagno
Jan 5, 2016·Journal of Gastroenterology·Tetsuhide ItoTooru Shimosegawa
May 21, 2009·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·László CzakóMakoto Otsuki
Jul 6, 2014·The Journal of Biological Chemistry·Aysha SamadJason I E Bruce
Apr 9, 2010·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Tetsuhide ItoRyoichi Takayanagi
Dec 2, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Mohsin AslamD Nageshwar Reddy

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