Pancreatic Duct Involvement in Well-Differentiated Neuroendocrine Tumors is an Independent Poor Prognostic Factor

Annals of Surgical Oncology
Yoshihide NannoYonson Ku

Abstract

The biological behavior of well-differentiated neuroendocrine tumors of the pancreas (PNETs) is difficult to predict. This study was designed to determine whether involvement of the main pancreatic duct (MPD) serves as a poor prognostic factor for PNETs. The involvement of the MPD in PNETs was defined as ductal stenosis inside the tumor mass associated with distal MPDs more than twofold larger in diameter than the proximal ducts. We examined the correlation between MPD involvement and other clinicopathological parameters, including nodal metastasis and recurrence-free survival, in 101 patients treated consecutively at three referral centers in Japan. All patients underwent surgical resection. MPD involvement was observed in 13 of the 101 cases (13%) and was associated with multiple unfavorable clinicopathological features (e.g., larger tumor size, higher histological grade, more frequent nodal metastasis, and higher recurrence rates). Patients with MPD involvement also showed significantly worse recurrence-free survival than did those without ductal involvement (P < 0.001), with a 5 years recurrence-free rate of 41%. On multivariate analysis, MPD involvement was significantly associated with nodal metastasis [odds ratio (OR) 16...Continue Reading

References

May 11, 2000·Gastrointestinal Endoscopy·T ObaraY Kohgo
Feb 17, 2001·Journal of Hepato-biliary-pancreatic Surgery·C E KitamiK Hatakeyama
Jul 6, 2004·Journal of Gastroenterology·Tomotaka AkatsuMasaki Kitajima
Jul 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Megan Dann FesinmeyerDeborah J Bowen
Oct 29, 2005·Best Practice & Research. Clinical Gastroenterology·Kjell Oberg, Barbro Eriksson
Oct 29, 2005·Best Practice & Research. Clinical Gastroenterology·Clive S Grant
Jun 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James C YaoDouglas B Evans
Aug 16, 2008·Gastroenterology·David C Metz, Robert T Jensen
Sep 19, 2012·Archives of Surgery·Geoffrey W KrampitzRobert T Jensen
Dec 14, 2012·World Journal of Gastroenterology : WJG·Masami OgawaTetsuya Mine
Aug 15, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Thomas CurranNabil Wasif
Jan 15, 2015·Journal of the National Comprehensive Cancer Network : JNCCN·Matthew H KulkeUNKNOWN National comprehensive cancer network
Dec 29, 2015·Journal of Surgical Oncology·Alexander KaltenbornHarald Schrem
Feb 7, 2016·The Journal of Surgical Research·Matthew A ShanahanSharon M Weber
Jun 24, 2016·Journal of Surgical Oncology·Lauren M PostlewaitShishir K Maithel
Jun 29, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Yoshihide NannoYonson Ku

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Citations

Jul 6, 2018·Expert Review of Anticancer Therapy·Lingaku LeeRobert T Jensen
Jul 29, 2020·Annals of Surgical Oncology·Masayuki TanakaThilo Hackert
Dec 8, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Woo Hyun PaikJae Hee Cho
Mar 21, 2021·Journal of Gastroenterology·Wen-Quan WangXian-Jun Yu
Oct 10, 2019·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·Stefano Francesco CrinóArmando Gabbrielli
Nov 18, 2018·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Ajay V MakerUNKNOWN members of the AHPBA Research Committee Consensus Conference

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