Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches

Radiation Oncology
Michael OrthKirsten Lauber

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor prognosis and rising incidence. Late detection and a particularly aggressive biology are the major challenges which determine therapeutic failure. In this review, we present the current status and the recent advances in PDAC treatment together with the biological and immunological hallmarks of this cancer entity. On this basis, we discuss new concepts combining distinct treatment modalities in order to improve therapeutic efficacy and clinical outcome - with a specific focus on protocols involving radio(chemo)therapeutic approaches.

References

Jul 1, 1979·International Journal of Radiation Oncology, Biology, Physics·M Quintiliani
May 1, 1997·Lancet·E E Vokes
Jul 21, 1999·Journal of the National Cancer Institute·S S Hecht
Nov 7, 2002·International Journal of Radiation Oncology, Biology, Physics·Donald J BuchsbaumKevin P Raisch
Apr 25, 2003·The New England Journal of Medicine·Eugenia E CalleMichael J Thun
Jan 23, 2004·Journal of Cellular Biochemistry·Deborah A AltomareJoseph R Testa
May 4, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mark S DuxburyEdward E Whang
Feb 3, 2006·Cancer Research·Kathryn E O'ReillyNeal Rosen
Nov 30, 2006·International Journal of Cancer. Journal International Du Cancer·Shin NakahiraMorito Monden
Mar 24, 2007·International Journal of Radiation Oncology, Biology, Physics·James D MurphyEdgar Ben-Josef
Apr 25, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Malcolm J MooreUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Oct 3, 2007·Cancer Research·Carolyn E ClarkRobert H Vonderheide
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Meredith A MorganTheodore S Lawrence
Dec 3, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brian M WolpinCharles S Fuchs
Jan 2, 2009·Cancer·Daniel T ChangAlbert C Koong
Mar 25, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric Van CutsemMalcolm J Moore
May 12, 2009·Immunological Reviews·Raul ElguetaRandolph J Noelle
Jul 2, 2009·International Journal of Cancer. Journal International Du Cancer·Soeren Torge MeesJoerg Haier
Aug 12, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Stephanie HehlgansNils Cordes
Nov 3, 2009·Cancer Cell·Sharon Y Gidekel FriedlanderTyler Jacks
Dec 5, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Atsushi MasamuneTooru Shimosegawa
Feb 10, 2010·International Journal of Cancer. Journal International Du Cancer·Sara H OlsonRobert C Kurtz
Mar 23, 2010·Cell·Osamu Takeuchi, Shizuo Akira
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Collin JacobsMax Schnurr
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Jul 8, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hedy Lee KindlerRichard M Goldberg
Jul 8, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip A PhilipCharles D Blanke
Jul 10, 2010·Radiation Oncology·Thomas B Brunner, Martin Scott-Brown
Sep 4, 2010·Nature Reviews. Cancer·John P MorrisMatthias Hebrok
Oct 29, 2010·Nature·Peter J CampbellP Andrew Futreal
Oct 29, 2010·Nature·Shinichi YachidaChristine A Iacobuzio-Donahue
Mar 16, 2011·Archives of Internal Medicine·Susan M GapsturMichael J Thun

❮ Previous
Next ❯

Citations

Jan 3, 2020·Current Topics in Medicinal Chemistry·Prashant DograManmeet Rawat
Sep 5, 2020·Immunity, Inflammation and Disease·Andrea F CruzFarzad Esni
Dec 22, 2019·Genes·Marina Ayres Pereira, Iok In Christine Chio
Jun 11, 2020·International Journal of Molecular Sciences·Christopher MontemagnoGilles Pagès
Mar 12, 2020·Journal of Clinical Medicine·Georgios A KaissisRickmer F Braren
May 14, 2020·International Journal of Molecular Sciences·Michael Karl MelzerAlexander Kleger
Jun 12, 2020·International Journal of Molecular Sciences·Sona CiernikovaBozena Smolkova
May 28, 2020·Cancers·Karolina Kaźmierczak-SiedleckaWojciech Makarewicz
Jun 11, 2020·Chemistry : a European Journal·Nicoló Zuin FantoniAndrew Kellett
Nov 26, 2020·International Journal of Molecular Sciences·Justin F CreedenRobert E McCullumsmith
Dec 3, 2020·International Journal of Molecular Sciences·Michela CortesiAnna Tesei
Nov 18, 2020·Cancers·Mithunah KrishnamoorthySaman Maleki Vareki
Dec 30, 2020·Journal of Clinical Medicine·Pilar Espiau-RomeraPatricia Sancho
Feb 1, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Patricia Santofimia-Castaño, Juan Iovanna
Oct 23, 2020·Journal of Labelled Compounds & Radiopharmaceuticals·Trevor FerrisEric O Aboagye
Apr 3, 2021·Molecular Biology Reports·Shruti GuptaKiran Kumar Tejavath
Apr 26, 2021·Advanced Drug Delivery Reviews·Marcel A HeinrichJai Prakash
Jun 1, 2021·Epigenetics : Official Journal of the DNA Methylation Society·I Gede Putu SupadmanabaElisa Giovannetti
Jun 3, 2021·Expert Opinion on Drug Discovery·Fabio BonioloMichael P Menden
Dec 24, 2020·Medicina·Giorgia ArcovitoPinuccia Faviana
May 21, 2021·Advanced Drug Delivery Reviews·Nuala Del PiccoloSteven C George
May 4, 2021·Gastroenterology·Nancy R GoughLopa Mishra

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase
exome-sequencing

Clinical Trials Mentioned

NCT01827553
NCT01728818
NCT02184195
NCT03300843
NCT03214250
NCT02715804
NCT02732938
NCT03778879
NCT03767582
NCT02648282

Software Mentioned

ACCEPT

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Related Papers

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
A Van den BroeckB Topal
International Journal of Biological Sciences
S Perwez Hussain
© 2021 Meta ULC. All rights reserved