Pancreatic Enzyme Replacement Therapy and Coefficient of Fat Absorption in Children and Adolescents With Cystic Fibrosis

Journal of Pediatric Gastroenterology and Nutrition
Janna W WoestenenkRoderick H J Houwen

Abstract

Pancreatic enzyme replacement therapy (PERT) is the proven therapy to substantially reduce fat malabsorption in patients with cystic fibrosis (CF). Few details of the daily practice regarding PERT and the resulting coefficient of fat absorption (CFA) are known. We therefore recorded the PERT and CFA in a large cohort of pancreatic insufficient pediatric patients with CF. We retrospectively studied 1719 completed 3-day dietary food records, including the pancreatic enzyme intake registrations, and 1373 CFA assessments of 224 patients with CF, ages 0-17 years. The clinical characteristics, PERT, expressed as an intake of lipase unit (LU) per gram of fat per day and LU per kilogram per day, and the CFA were described for the group as a whole and separately for those on enteral tube feeding. Cross-sectional relationship between the CFA and the LU per gram of fat per day and LU per kilogram per day were determined for each year of age. We also addressed the effect of the interventions done in patients with CFA outcomes <85%. The LU per gram of fat per day was relatively stable throughout the age groups, whereas the LU per kilogram per day fell markedly with age. The median CFA in the age group 17 varied between 86% and 91%, however,...Continue Reading

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Citations

May 16, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Janna W WoestenenkRoderick H J Houwen
Apr 7, 2016·Journal of Pediatric Gastroenterology and Nutrition·Virginia A StallingsWalter A Shaw
May 17, 2019·Expert Review of Respiratory Medicine·Carla ColomboGianfranco Alicandro
Sep 20, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Senthilkumar SankararamanThomas J Sferra
Feb 12, 2017·BMC Medicine·Maarten R StruyvenbergSteven D Freedman
Jul 28, 2017·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Joaquim Calvo-LermaCarmen Ribes-Koninckx
Aug 3, 2021·The Cochrane Database of Systematic Reviews·Christabella NgAlan R Smyth

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Software Mentioned

SPSS
Statistical Package for the Social Sciences program ( SPSS
PERT

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