Pancreatic enzyme replacement therapy for young cystic fibrosis patients

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
Anne MunckFriederike Henniges

Abstract

Maldigestion in cystic fibrosis (CF) affects approximately 90% of patients. As soon as pancreatic insufficiency is identified, enzyme supplementation is prescribed even with breast fed infants. A pancreatic enzyme preparation developed particularly for infants, Creon for children (CfC), contains smaller granules to be administered with a dosing spoon (5000 lipase units per scoop). In a prospective, randomised, multi-centre study, 40 infants and toddlers received both CfC and Creon 10000 (C10) for two weeks each in a cross-over design. Dosing of pancreatic enzymes was continued as applied before the study. The primary endpoint was the parents' treatment preference. Secondary endpoints included coefficient of fat absorption (CFA), clinical symptoms and safety parameters. 20 parents (51%) from the N=39 intent to treat sample preferred CfC, 9 (23%) preferred C10, and 10 (26%) had no preference The applied doses led to a mean CFA with similar results for both treatments (77.8% vs. 78.7%). Gastrointestinal symptoms were reported on a number of study days, and some children had abnormal results for laboratory parameters of malabsorption. Safety and tolerability of the preparations were good and all these parameters were comparable for...Continue Reading

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Citations

Feb 19, 2011·American Journal of Respiratory and Critical Care Medicine·Malena Cohen-CymberknohEitan Kerem
Apr 9, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Hariharan RameshVinay Thorat
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Aug 16, 2016·The Journal of Pharmacy and Pharmacology·Punam MistryUNKNOWN SPaeDD-UK project (Smart Paediatric Drug Development - UK)
Nov 24, 2016·The Cochrane Database of Systematic Reviews·Usha Rani Somaraju, Arturo Solis-Moya
Jun 23, 2011·Journal of Pediatric Gastroenterology and Nutrition·Els Van de VijverGigi Veereman-Wauters
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Jul 23, 2014·Journal of Pediatric Gastroenterology and Nutrition·Jamie L WooldridgeRuth Thieroff-Ekerdt
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Aug 8, 2020·The Cochrane Database of Systematic Reviews·Usha Rani R Somaraju, Arturo Solis-Moya
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Aug 11, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ariane MendenGhania Ait-Ghezala

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