PMID: 9443125Jan 27, 1998Paper

Pancreatic enzyme supplementation in cystic fibrosis patients before and after fibrosing colonopathy

Journal of Pediatric Gastroenterology and Nutrition
J C StevensS K Chong

Abstract

In 1994 we cared for nine cystic fibrosis patients with fibrosing colonopathy. To evaluate the relationship between fibrosing colonopathy and supplemental pancreatic enzymes we reviewed our dosing of enzymes prior to fibrosing colonopathy development and then evaluated the subsequent effect of drastically reducing pancreatic enzyme dose. We retrospectively reviewed pancreatic enzyme dosing for 267 cystic fibrosis patients with pancreatic insufficiency. The supplemental enzyme history of nine patients with fibrosing colonopathy was contrasted with the history of 258 nonaffected patients. The pancreatic enzyme doses of 75 patients taking at least 6,000 U lipase/kg/meal were systematically reduced to approximately 2,000 lipase units/kg/meal. We evaluated the effect of this dose reduction on change in height and weight z scores one year after achievement of stable enzyme dose. In the year prior to diagnosis patients with fibrosing colonopathy took a significantly larger pancreatic enzyme dose, whether assessed by highest dose or cumulative dose, than did nonaffected patients. Similar results were observed after controlling for sex and age. All 75 patients on at least 6,000 U lipase/kg/meal were able to tolerate a significant reduct...Continue Reading

References

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Citations

Sep 12, 2000·Current Gastroenterology Reports·J D Lloyd-StillR M Kimura
Oct 30, 2001·Clinical Imaging·M AlmbergerR Passariello
Sep 28, 2002·Journal of Pediatric Gastroenterology and Nutrition·Christopher J Taylor
Sep 28, 2002·Journal of Pediatric Gastroenterology and Nutrition·Daniela Elena SerbanNicolae Miu
Aug 30, 2005·American Journal of Respiratory and Critical Care Medicine·Pamela B Davis
Oct 26, 2011·European Journal of Medical Research·G TerheggenL Leifeld
Oct 14, 2008·Drug Development and Industrial Pharmacy·Sonali Raosaheb NaikwadeAmrita Narayan Bajaj
Jul 26, 2006·Journal of the American Dietetic Association·Mary Sue BradyJohn C Stevens
Aug 13, 2011·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Drucy BorowitzUNKNOWN Liprotamase 726 Study Group
Jun 22, 2018·Journal of Pediatric Gastroenterology and Nutrition·Maisam Abu-El-HaijaVeronique D Morinville
May 29, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Tamaki IkuseToshiaki Shimizu
Nov 13, 2019·Pediatric Pulmonology·Kimberly AltmanKaren Maguiness
Jun 1, 1999·Journal of Genetic Counseling·T Brown, E L Schwind
Sep 3, 1999·Journal of the Royal Society of Medicine·J M Littlewood
Jan 5, 2000·Clinical Pediatrics·R Wyllie
Oct 20, 2010·The Medical Journal of Australia·James ToouliUNKNOWN Australasian Pancreatic Club

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