Pancreatic exocrine insufficiency and cardiovascular risk in patients with chronic pancreatitis: A prospective, longitudinal cohort study

Journal of Gastroenterology and Hepatology
Daniel de la IglesiaJuan Enrique Domínguez-Muñoz

Abstract

Previous studies have suggested that chronic pancreatitis (CP) is associated with increased risk of cardiovascular (CV) disease independently of other major risk factors. We evaluated the risk of CV events in a well-phenotyped cohort of patients with CP and its association with pancreatic exocrine insufficiency (PEI) among other CV risk factors. This was a prospective, longitudinal cohort study of patients with CP, followed up at the Pancreas Unit of the University Hospital of Santiago de Compostela, Spain. Four hundred thirty patients were included (mean 47.8 ± 14.4 years of age, 79.1% male). Mean follow-up was 8.6 ± 4.6 years. CP etiology was toxic (alcohol and/or smoking) in 290 patients (67.4%). PEI and pancreatogenic diabetes mellitus (DM) were present in 29.3% and 29.5% of the patients, respectively. A total of 45 CV events was recorded (10.5%); 21 patients had a major CV event (stroke or myocardial infarction) and 27 developed clinically relevant peripheral arterial disease. A higher incidence of CV events was recorded in patients with PEI than in those without (incidence rate ratio 3.67, 95% confidence interval [CI] 1.92-7.24; P < 0.001). In the multivariate analysis, PEI without DM (OR 4.96; 95% CI 1.68 to 14.65), coex...Continue Reading

References

Jul 1, 1984·Gut·M Sarner, P B Cotton
Aug 1, 1982·Digestive Diseases and Sciences·L GulloG Labò
Feb 17, 2001·Gastroenterology·B Etemad, D C Whitcomb
Jan 9, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Bruce A CooperCarol A Pollock
Dec 7, 2007·Journal of Magnetic Resonance Imaging : JMRI·N Cem BalciFrank R Burton
Dec 20, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Erin D Michos, Michal L Melamed
Feb 27, 2009·Gastrointestinal Endoscopy·Marc F CatalanoLyndon V Hernandez
Aug 13, 2010·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Sinéad DugganKevin Conlon
Sep 25, 2010·Journal of the American Society of Nephrology : JASN·Gabriel ContrerasUNKNOWN African-American Study of Kidney Disease, and Hypertension Study Group
Feb 26, 2011·Journal of Gastroenterology and Hepatology·J Enrique Domínguez-Muñoz
Feb 22, 2012·Gastroenterology & Hepatology·Paolo Giorgio Arcidiacono
Aug 18, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Björn LindkvistJulio Iglesias-Garcia
May 31, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Edmée C M SikkensMarco J Bruno
Nov 22, 2013·World Journal of Gastroenterology : WJG·Christina BrockAsbjørn Mohr Drewes
Nov 22, 2013·World Journal of Gastroenterology : WJG·Henrik Højgaard RasmussenMette Holst
Dec 3, 2013·Indian Journal of Surgical Oncology·Vasiliki Th KaragianniJohn K Triantafillidis
Jun 4, 2014·Radiologic Clinics of North America·Erin O'NeillFrank H Miller
Nov 2, 2014·United European Gastroenterology Journal·Philippe LévyPatrick Maisonneuve
Jan 6, 2015·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Tetsuo ShojiMasaaki Inaba
Jul 7, 2015·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Mary E Phillips
Aug 6, 2015·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Björn LindkvistJ Enrique Domínguez-Muñoz
Feb 8, 2018·Gastroenterology Clinics of North America·J Enrique Domínguez-Muñoz, Mary Phillips

❮ Previous
Next ❯

Citations

Jun 21, 2019·Current Opinion in Gastroenterology·J Enrique Dominguez-Muñoz
Dec 6, 2019·World Journal of Gastroenterology : WJG·Sara NikolicMiroslav Vujasinovic
Jun 10, 2020·European Journal of Gastroenterology & Hepatology·Wisam SbeitTawfik Khoury
Mar 18, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S Powell-BrettK Roberts
Aug 2, 2021·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Laura Uribarri-GonzalezJ Enrique Dominguez-Muñoz
Jun 3, 2021·Current Opinion in Gastroenterology·Mark O GoodarziPhil A Hart

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.