Pancreatic Fibroblast Heterogeneity: From Development to Cancer.

Cells
Paloma E GarciaMarina Pasca Di Magliano

Abstract

Pancreatic ductal adenocarcinoma (PDA) is characterized by an extensive fibroinflammatory microenvironment that accumulates from the onset of disease progression. Cancer-associated fibroblasts (CAFs) are a prominent cellular component of the stroma, but their role during carcinogenesis remains controversial, with both tumor-supporting and tumor-restraining functions reported in different studies. One explanation for these contradictory findings is the heterogeneous nature of the fibroblast populations, and the different roles each subset might play in carcinogenesis. Here, we review the current literature on the origin and function of pancreatic fibroblasts, from the developing organ to the healthy adult pancreas, and throughout the initiation and progression of PDA. We also discuss clinical approaches to targeting fibroblasts in PDA.

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Citations

Apr 20, 2021·Frontiers in Endocrinology·David J EastyBryan T Hennessy
Oct 1, 2021·Cancer Metastasis Reviews·Cameron J HertingGregory B Lesinski

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Methods Mentioned

BETA
flow cytometry
single cell sequencing
RNA-seq
transgenic

Clinical Trials Mentioned

NCT04177810
NCT02550327

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