Pancreatic glucagon does not alter intrameal gastric emptying of milk in the rat

Physiology & Behavior
Z Stockinger, N Geary

Abstract

The hypothesis that pancreatic glucagon (PG) inhibits feeding by altering intrameal gastric emptying was tested in nondeprived rats at midday, conditions under which exogenous PG is thought to elicit satiety. Rats received intraperitoneal injections of PG (400 or 800 micrograms/kg), cholecystokinin (CCK, 0.5 or 1.0 micrograms/kg) or saline and were given bolus intragastric infusions of 10 ml evaporated milk through chronic gastric cannulae. PG did not affect volumes of stomach contents recovered 20 minutes postinjection. In contrast, CCK inhibited gastric emptying in a dose-related manner. When milk was offered to the same rats to drink, 400 micrograms/kg PG significantly reduced meal size. These findings suggest that PG's satiety effect is not caused by its effect on stomach emptying.

References

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Jan 1, 1987·Physiology & Behavior·V HintonN Geary
Jan 1, 1983·Progress in Neurobiology·J A Deutsch
Jan 1, 1980·Scandinavian Journal of Gastroenterology·J Christiansen
Feb 1, 1982·Physiology & Behavior·N Geary, G P Smith

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Citations

Jul 4, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Stephen C WoodsWolfgang Langhans
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·N Geary
Mar 1, 1993·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·J ArbósJ M Argilés

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