Pancreatic HB9 protein level is affected by early life stress in young adult rats: possible involvement of TNF-α and corticosterone.

Archives of Physiology and Biochemistry
Forouzan SadeghimahalliHomeira Zardooz

Abstract

This study examined foot shock stress effects, during weaning, on pancreatic HB9 protein expression in young adult male rats in the presence or absence of adulthood stress. The pups were divided into Control, Early life stress, Young adult stress, and Early + young adult stress groups. Plasma corticosterone, insulin, glucose, and TNF-α concentrations, and pancreatic HB9 protein expression were assessed. At 2 weeks of age, stress increased plasma corticosterone level. During young adulthood, plasma TNF-α and glucose concentrations increased, whereas plasma insulin and pancreatic HB9 protein levels decreased in Early life stress group. Whereas, Early + young adulthood stress group showed no change in the study parameters, except for plasma corticosterone and insulin concentrations. Overall, early life stress reduced pancreatic HB9 protein expression possibly by elevating plasma corticosterone and TNF-α levels in early life and adulthood, respectively. However, combined with adulthood stress, HB9 protein expression increased to the level of Control.

References

May 13, 1999·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·G S Hotamisligil
Mar 29, 2000·Progress in Brain Research·C O LaddP M Plotsky
Nov 10, 2000·Laboratory Animals·M FluttertM S Oitzl
Mar 29, 2001·Diabetes·H Edlund
Dec 20, 2002·Mechanisms of Development·Maria E WilsonMichael S German
Feb 21, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sylvie DurantFrançoise Homo-Delarche
Jul 21, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M L AndersenS Tufik
Jun 15, 2007·The European Journal of Neuroscience·Melanie LippmannLisa M Monteggia
Jun 26, 2007·Journal of Psychosomatic Research·S ChandrashekaraYeragani K Vikram
Jul 4, 2008·The New England Journal of Medicine·Peter D GluckmanKent L Thornburg
Aug 9, 2008·Molecular and Cellular Endocrinology·Andreia S BernardoKevin Docherty
Jun 18, 2009·Pediatric Research·Ronald J McPhersonSandra E Juul
Jun 28, 2011·Pediatrics and Neonatology·Ming-Chi Lai, Li-Tung Huang
Apr 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sheldon CohenRonald B Turner
May 5, 2012·Diabetes/metabolism Research and Reviews·Jacqueline L Beaudry, Michael C Riddell
Nov 6, 2012·Journal of Zhejiang University. Science. B·Fatemeh RostamkhaniBabak Farrokhi
Aug 27, 2013·Psychosomatic Medicine·Peter J Gianaros, Daniel A Hackman
Jul 3, 2015·International Journal of Endocrinology·Li ChenFengxia Liang
Dec 4, 2016·Journal of Biomedical Science·Kanwal Rehman, Muhammad Sajid Hamid Akash
Jan 21, 2017·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Camelia E HostinarGregory E Miller
Jul 6, 2017·Frontiers in Human Neuroscience·Yun-Zi LiuChun-Lei Jiang
Jan 2, 2018·Psychoneuroendocrinology·Jolene Masters PedersenRikke Lund

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