Pancreatic insulikn-, glucagon-, and somatostatin-positive islet cell populatins during the perinatal development of the rat. I. Morphometric quantitation

Biology of the Neonate
R C McEvoy, K L Madson

Abstract

Pancreatic insulin-, glucagon- and somatostatin-positive islet cell volumes were quantitated morphometrically during the developmental interval from 16 days post coitum to 10 days postnatal. There was a rapid increase in the alpha- and beta-cell populations during late fetal life. The beta-cells increased more rapidly and comprised the major portion of the islets after the 20th fetal day. After birth the rate of increase of both beta- and alpha-cells decreased but was greater than that of the surrounding exocrine pancreas during the early period of postnatal life. This resulted in an islet cell percentage of 5-6% of the total pancrease on day 6 postnatal. delta-Cells were present before birth but increased in volume density within the islet cell after birth. The implications of these morphological data to the interpretation of physiological studies are discussed.

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