Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions

The American Journal of Surgical Pathology
R H HrubanG J Offerhaus

Abstract

Proliferative epithelial lesions in the smaller caliber pancreatic ducts and ductules have been the subject of numerous morphologic, clinical, and genetic studies; however, a standard nomenclature and diagnostic criteria for classifying these lesion have not been established. To evaluate the uniformity of existing systems for grading duct lesions in the pancreas, 35 microscopic slides with 35 representative duct lesions were sent to eight expert pathologists from the United States, Canada, and Europe. Kappa values for interobserver agreement could not be calculated initially because more than 70 different diagnostic terms were used by the eight pathologists. In several cases, the diagnoses rendered for a single duct lesion ranged from "hyperplasia," to "metaplasia," to "dysplasia," to "carcinoma in situ." This review therefore demonstrated the need for a standard nomenclature and classification system. Subsequently, during a working group meeting, the pathologists agreed to adopt a single standard system. The terminology pancreatic intraepithelial neoplasia (or PanIN) was selected, and diagnostic criteria for each grade of PanIN were established (http://pathology.jhu.edu/pancreas_panin). This new system was then evaluated by ha...Continue Reading

References

Apr 1, 1979·Cancer·S KozukaM Takeuchi
Jul 1, 1969·Obstetrical & Gynecological Survey·R M Richart
Feb 1, 1982·American Journal of Clinical Pathology·P M PourG Sayed
Oct 1, 1994·Human Pathology·R C Haggitt
Jun 1, 1994·American Journal of Clinical Pathology·J A DiGiuseppeG J Offerhaus
Dec 10, 1998·Annals of Diagnostic Pathology·E BrockieJ Albores-Saavedra
Dec 11, 1999·Virchows Archiv : an International Journal of Pathology·J LüttgesG Klöppel
Jun 15, 2000·The American Journal of Pathology·R H HrubanS E Kern
Jun 15, 2000·The American Journal of Pathology·M YamanoT Shirai
Jul 6, 2000·The American Journal of Pathology·E HeinmöllerJ Rüschoff

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Citations

Dec 23, 2003·Pathology Oncology Research : POR·Attila Zalatnai
Oct 1, 2005·Pathology Oncology Research : POR·Gábor ElekAkos Pap
Jun 26, 2012·The Journal of Membrane Biology·Joell L SolanPaul D Lampe
Jan 5, 2005·Der Pathologe·J Lüttges, G Klöppel
Jul 30, 2010·Der Pathologe·A Tannapfel
Sep 13, 2011·Der Pathologe·B Sipos, T Henopp
May 6, 2009·European Radiology·Sung Soo AhnJoon Seok Lim
Feb 20, 2008·Langenbeck's Archives of Surgery·Jan-Bart M KoorstraAnirban Maitra
Jul 16, 2005·Virchows Archiv : an International Journal of Pathology·Sönke DetlefsenGünter Klöppel
Jul 22, 2006·Journal of Hepato-biliary-pancreatic Surgery·Norihiro Sato, Michael Goggins
May 19, 2006·Journal of Hepato-biliary-pancreatic Surgery·Hirofumi TanaseBunsei Nobukawa
May 24, 2007·Journal of Hepato-biliary-pancreatic Surgery·Kyoichi Takaori
May 24, 2007·Journal of Hepato-biliary-pancreatic Surgery·Georg FeldmannAnirban Maitra
May 24, 2007·Journal of Hepato-biliary-pancreatic Surgery·Noriyoshi Fukushima, Masashi Fukayama
May 24, 2007·Journal of Hepato-biliary-pancreatic Surgery·Kohji NagataSuguru Yonezawa
May 24, 2007·Journal of Hepato-biliary-pancreatic Surgery·Ralph H HrubanMichael Goggins
Oct 7, 2008·Journal of Hepato-biliary-pancreatic Surgery·Takayuki AimotoTakashi Tajiri
Apr 1, 2009·Journal of Hepato-biliary-pancreatic Surgery·Yoshiki NaitoHirohisa Yano
Dec 19, 2007·Journal of Gastroenterology·Osamu TakasawaTakashi Sawai
Jun 22, 2012·Medical Molecular Morphology·Yoko MatsudaToshiyuki Ishiwata
Apr 23, 2008·Cancer Metastasis Reviews·Alexios StrimpakosKostas N Syrigos
Nov 2, 2012·Cancer Metastasis Reviews·Wanglong Qiu, Gloria H Su
May 25, 2011·Japanese Journal of Radiology·Seiko Kuroki-SuzukiNoriyuki Moriyama
Sep 17, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Xiaoming ShenJoseph Kim
Aug 19, 2005·Current Treatment Options in Oncology·Teresa A Brentnall
Jun 12, 2004·Current Gastroenterology Reports·Günter Klöppel, Jutta Lüttges
Sep 5, 2003·Current Treatment Options in Gastroenterology·Supot Pongprasobchai, Suresh T. Chari
Sep 4, 2004·Current Treatment Options in Gastroenterology·Harold FruchtRobert L. Fine
Feb 3, 2011·Journal of Gastrointestinal Cancer·Amanda L Rynearson, Caroline R Sussman
Feb 22, 2011·Journal of Gastrointestinal Cancer·Adrienne GrzendaRaul Urrutia
Jun 9, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J L SotoA Carrato
Aug 3, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P Pérez SeguraE Aranda
Oct 23, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wenjun LiXuqing Wang
Jan 12, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Marta Herreros-VillanuevaLuis Bujanda
Jun 14, 2003·Gastroenterology·Francisco X Real
Jun 27, 2003·International Journal of Radiation Oncology, Biology, Physics·Ross A Abrams
Aug 4, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael J Levy, Jonathan E Clain

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