PMID: 2510155Oct 1, 1989Paper

Pancreatic islet-specific T-cell clones from nonobese diabetic mice

Proceedings of the National Academy of Sciences of the United States of America
K HaskinsB J Bradley

Abstract

We have produced a panel of islet-specific T-cell clones from nonobese diabetic (NOD) mice. These clones proliferate and make interleukin 2 in an antigen-specific manner in response to NOD antigen-presenting cells and islet cells. Most of the clones respond to islet-cell antigen from different mouse strains but only in the presence of antigen-presenting cells bearing the class II major histocompatibility complex of the NOD mouse. In vivo, the clones mediate the destruction of islet, but not pituitary, grafts. Furthermore, pancreatic sections from a disease transfer experiment with one of the clones showed a pronounced cellular infiltration and degranulation of islets in nondiabetic (CBA x NOD)F1 recipients.

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Oct 1, 1988·Diabetes·K HaskinsK Lafferty
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Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H Acha-Orbea, H O McDevitt
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Citations

Sep 23, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A I RamsinghS Tracy
Mar 1, 1991·Diabetes/metabolism Reviews·C BoitardJ F Bach
Sep 1, 1994·Diabetologia·C BoitardJ F Bach
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Feb 9, 2010·Nature Immunology·Brian D StadinskiKathryn Haskins
May 26, 1999·Clinical and Experimental Immunology·A Hartemann-HeurtierC Boitard
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S CandéiasK Haskins
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D EliasI R Cohen
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C BoitardJ F Bach
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S C Smith, P M Allen
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Nov 26, 2004·American Journal of Respiratory and Critical Care Medicine·Laimute Taraseviciene-StewartNorbert F Voelkel

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