PMID: 9187635Jun 1, 1997Paper

Pancreatic islet transplantation improves body composition, decreases energy intake and normalizes energy efficiency in previously diabetic female rats

The Journal of Nutrition
B TobinM J Marchello

Abstract

We investigated the weight gain, body composition, and feed efficiency of female Wistar Furth rats (170 +/- 1 g) made diabetic with streptozotocin (55 mg/kg intravenously), then infused intraportally with 3519 +/- 838 (150 mu equivalent units) syngeneic pancreatic islets of Langerhans. After islet transplants (5-6 wk), nutritional energetics were evaluated in transplanted rats (Transplant), and also in 3- and 9-wk diabetic (Diab-3, 9) and control rats treated with sham infusions and similar surgical manipulations (Sham-3, 9). Diabetic rats demonstrated marked hyperphagia, which was corrected by islet transplantation (577 +/- 53 vs. 266 +/- 19 kJ/d; P < 0.0001) and was not different than sham control rats (285 +/- 24 kJ/d; P > 0.05). Three weeks of diabetes resulted in a lower protein (Diab-3, 24.8 +/- 2.6 g vs. Sham-3, 30.9 +/- 1.0 g) and fat content (1.9 +/- 0.8 g vs. 11.6 +/- 1.7 g) in the rats' carcasses. However, 6 wk after islet transplantation, rats receiving islets (Transplant) were not different than control rats (Sham-9) (31.9 +/- 1.7 g vs. 33.3 +/- 1.9 g protein and 15.4 +/- 3.0 g vs. 15.1 +/- 3.2 g fat). Three weeks of diabetes resulted in a lesser energy efficiency compared with Sham rats (2.7 +/- 2.0 vs. 7.1 +/- 1....Continue Reading

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