Pancreatic islet transplantation has become an established approach to β-cell replacement therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet isolation, islet culture, and peritransplant management of the islet transplant recipient has resulted in substantial improvements in metabolic and safety outcomes for patients. For patients requiring total or subtotal pancreatectomy for benign disease of the pancreas, isolation of islets from the diseased pancreas with intrahepatic transplantation of autologous islets can prevent or ameliorate postsurgical diabetes, and for patients previously experiencing painful recurrent acute or chronic pancreatitis, quality of life is substantially improved. For patients with type 1 diabetes or insulin-deficient forms of pancreatogenic (type 3c) diabetes, isolation of islets from a deceased donor pancreas with intrahepatic transplantation of allogeneic islets can ameliorate problematic hypoglycemia, stabilize glycemic lability, and maintain on-target glycemic control, consequently with improved quality of life, and often without the requirement for insulin therapy. Because the metabolic benefits are dependent on the numbers of islets transplanted that sur...Continue Reading
Role of glucagon, catecholamines, and growth hormone in human glucose counterregulation. Effects of somatostatin and combined alpha- and beta-adrenergic blockade on plasma glucose recovery and glucose flux rates after insulin-induced hypoglycemia
Autotransplantation of pancreatic fragments to the portal vein and spleen of totally pancreatectomized dogs: a comparative evaluation
Abnormal sensitivity to glucose of human islets cultured in a high glucose medium: partial reversibility after an additional culture in a normal glucose medium.
Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after 1 episode of hypoglycemia in nondiabetic humans.
The effect of islet cell culture in vitro at 24 degrees C on graft survival and MHC antigen expression
Purified canine islet autografts. Functional outcome as influenced by islet number and implantation site
Type I diabetes is characterized by insulin resistance not only with regard to glucose, but also to lipid and amino acid metabolism
Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect
Insulin sensitivity in pancreatitis, liver diseases, steroid treatment and hyperthyroidism assessed by glucose, insulin and somatostatin infusion
Total or near total pancreatectomy and islet autotransplantation for treatment of chronic pancreatitis
Persistence of counter-regulatory abnormalities in insulin-dependent diabetes mellitus after pancreas transplantation
Intraportal transplantation of pancreatic islets into livers of diabetic rats. Reinnervation of islets and regulation of insulin secretion by the hepatic sympathetic nerves
Acceleration of chronic failure of intrahepatic canine islet autografts by a short course of prednisone
Hyperproinsulinemia is associated with increased beta cell demand after hemipancreatectomy in humans
The defective glucagon response from transplanted intrahepatic pancreatic islets during hypoglycemia is transplantation site-determined
Progressive islet graft failure occurs significantly earlier in autoantibody-positive than in autoantibody-negative IDDM recipients of intrahepatic islet allografts
Successful islet autotransplantation in humans: functional insulin secretory reserve as an estimate of surviving islet cell mass
Immediate insulin-independence after retransplantation of islets prepared from an allograft pancreatectomy in a type 1 diabetic patient
Insulin deficiency and increased intact and 32/33 split proinsulin secretion following human islet autotransplantation
Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients
BETA-2 score is an early predictor of graft decline and loss of insulin independence after pancreatic islet allotransplantation.
Co-localized immune protection using dexamethasone-eluting micelles in a murine islet allograft model.
Shielding islets with human amniotic epithelial cells enhances islet engraftment and revascularization in a murine diabetes model.
Integration of nano- and biotechnology for beta-cell and islet transplantation in type-1 diabetes treatment
Islet Transplantation to the Anterior Chamber of the Eye-A Future Treatment Option for Insulin-Deficient Type-2 Diabetics? A Case Report from a Nonhuman Type-2 Diabetic Primate.
Challenges and practical realities of long-term patient follow-up in three xeno-islet clinical trials: The experience in pig islet xenotransplantation trials in New Zealand and Argentina.
Islet Transplantation in the Lung via Endoscopic Aerosolization: Investigation of Feasibility, Islet Cluster Cell Vitality, and Structural Integrity.
Stem Cell-Derived Islets: Next Steps for Histologic and Functional Assessment During Development as a Cellular Therapy for the Treatment of Diabetes
Hypoglycemia-associated autonomic failure, counterregulatory responses, and therapeutic options in type 1 diabetes
Performance of modified Igls criteria to evaluate islet autograft function after total pancreatectomy with islet autotransplantation - a retrospective study.
Dose-dependent effects of necrostatin-1 supplementation to tissue culture media of young porcine islets.
Diabetes Mellitus Is a Chronic Disease that Can Benefit from Therapy with Induced Pluripotent Stem Cells.
Factors Associated With Morbidity Following Total Pancreatectomy and Islet Autotransplantation: A NSQIP Analysis.
Inhibition of Dectin-1 on Dendritic Cells Prevents Maturation and Prolongs Murine Islet Allograft Survival.
NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferation.
Bioluminescence Imaging In Vivo Confirms the Viability of Pancreatic Islets Transplanted into the Greater Omentum.
Pancreas transplant versus islet transplant versus insulin pump therapy: in which patients and when?
Bionic Organs: Shear Forces Reduce Pancreatic Islet and Mammalian Cell Viability during the Process of 3D Bioprinting.
Heterogeneity and neurovascular integration of intraportally transplanted islets revealed by 3-D mouse liver histology.
Feasibility of large experimental animal models in testing novel therapeutic strategies for diabetes.
Effects of islet transplantation on microvascular and macrovascular complications in type 1 diabetes.
What Is New with Total Pancreatectomy and Autologous Islet Cell Transplantation? Review of Current Progress in the Field.
A Strategy to Simultaneously Cure Type 1 Diabetes and Diabetic Nephropathy by Transplant of Composite Islet-Kidney Grafts.
Designing biomaterials for the modulation of allogeneic and autoimmune responses to cellular implants in Type 1 Diabetes.
3D Collagen Hydrogel Promotes In Vitro Langerhans Islets Vascularization through ad-MVFs Angiogenic Activity.
Autoimmune Diabetes & Tolerance
Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.