Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions

Endocrine Reviews
Michael R Rickels, R Paul Robertson


Pancreatic islet transplantation has become an established approach to β-cell replacement therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet isolation, islet culture, and peritransplant management of the islet transplant recipient has resulted in substantial improvements in metabolic and safety outcomes for patients. For patients requiring total or subtotal pancreatectomy for benign disease of the pancreas, isolation of islets from the diseased pancreas with intrahepatic transplantation of autologous islets can prevent or ameliorate postsurgical diabetes, and for patients previously experiencing painful recurrent acute or chronic pancreatitis, quality of life is substantially improved. For patients with type 1 diabetes or insulin-deficient forms of pancreatogenic (type 3c) diabetes, isolation of islets from a deceased donor pancreas with intrahepatic transplantation of allogeneic islets can ameliorate problematic hypoglycemia, stabilize glycemic lability, and maintain on-target glycemic control, consequently with improved quality of life, and often without the requirement for insulin therapy. Because the metabolic benefits are dependent on the numbers of islets transplanted that sur...Continue Reading


Mar 1, 1977·Diabetes·R C GriffithP E Lacy
Jun 1, 1992·The Journal of Clinical Investigation·E R Seaquist, R P Robertson
Jun 1, 1991·The Journal of Clinical Endocrinology and Metabolism·M P DiamondR S Sherwin
Jul 1, 1990·Acta diabetologica latina·C RicordiR Alejandro
Sep 30, 1988·Biochemical and Biophysical Research Communications·R M StrieterS L Kunkel
Nov 1, 1989·Diabetes Care·R J Sjoberg, G S Kidd
May 1, 1988·Transplantation·G L WarnockJ Egebjerg
Apr 1, 1988·Diabetes·C RicordiD W Scharp
Aug 1, 1987·Diabetes·H Yki-JärvinenV A Koivisto
Oct 1, 1985·Metabolism: Clinical and Experimental·S Zuniga-Guajardo, B Zinman
Jan 1, 1984·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·H YasudaY Shigeta
Dec 1, 1984·The Journal of Clinical Investigation·H MaruyamaR H Unger
Feb 1, 1984·The Journal of Clinical Endocrinology and Metabolism·J B JaspanE Rayfield
Jan 15, 1996·The Journal of Clinical Investigation·E R SeaquistR P Robertson
Jan 1, 1996·Journal of Pediatric Surgery·D C WahoffD E Sutherland
Sep 19, 1996·The New England Journal of Medicine·G TydénJ Bolinder
Jun 1, 1997·Transplantation Proceedings·B J OlackT Mohanakumar
Jun 12, 1999·American Journal of Surgery·J M RabkinD E Sutherland

❮ Previous
Next ❯


Oct 10, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Piotr J BachulPiotr Witkowski
Oct 28, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Purushothaman KuppanAndrew R Pepper
Nov 11, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·A J S FlattJ A M Shaw
Dec 11, 2019·Nutrients·Marco InfanteRodolfo Alejandro
Feb 8, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Fanny LebretonEkaterine Berishvili
Aug 19, 2020·Endocrinology·Betty R LawtonDiane S Krause
Oct 2, 2020·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Siddharth NarayananChristopher M Jones
Aug 28, 2020·World Journal of Diabetes·Ayan RoyBiju Pottakkat
Jul 10, 2020·Stem Cell Research & Therapy·Shuai ChenChunlin Zou
Oct 7, 2020·International Journal of Molecular Sciences·Stephane DemineDecio L Eizirik
Oct 8, 2020·Journal of Biophotonics·Aline ZbindenKatja Schenke-Layland
Oct 7, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Kendall R McEachronMelena D Bellin
Jan 24, 2021·Advanced Drug Delivery Reviews·Bhushan N KharbikarTejal A Desai
Feb 8, 2021·Annals of the New York Academy of Sciences·Anneliese J S FlattMichael R Rickels
Oct 15, 2020·Advanced Healthcare Materials·Eloïse LebaudyVarvara Gribova
Nov 3, 2020·Stem Cells International·Takahiro TeshimaHidekazu Koyama
Nov 22, 2020·International Journal of Molecular Sciences·Felipe ArroyaveFernando Lizcano
Jan 8, 2021·Global Health & Medicine·Takuya AwataMasayuki Shimoda
Feb 3, 2021·The Journal of Clinical Investigation·Anna LamKevan C Herold
Feb 6, 2021·Disease-a-month : DM·Berrin Ergun-LongmireDonald E Greydanus
Dec 18, 2020·Global Health & Medicine·Tadashi Takaki, Masayuki Shimoda
Jan 22, 2021·Diabetes·Aaron L GliebermanKevin Kit Parker
Oct 31, 2020·Stem Cell Research & Therapy·Idil I Aigha, Essam M Abdelalim
Feb 19, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Zuzana HladíkováFrantišek Saudek
Mar 3, 2021·Current Opinion in Organ Transplantation·Riccardo Tamburrini, Jon S Odorico
Mar 5, 2021·Frontiers in Immunology·Shiva Pathak, Everett H Meyer
Jun 24, 2020·Seminars in Pediatric Surgery·Appakalai N BalamuruganJaimie D Nathan
Mar 25, 2021·The Journal of Clinical Investigation·Alvin C Powers
Apr 27, 2021·American Journal of Physiology. Endocrinology and Metabolism·Chien-Chia ChenShiue-Cheng Tang
Apr 24, 2021·World Journal of Diabetes·Masaki NagayaHiroshi Nagashima
Mar 30, 2021·Diabetic Medicine : a Journal of the British Diabetic Association·Laura ReidShareen Forbes
Jun 24, 2021·Nature Metabolism·Martin G MyersMichael W Schwartz
Jul 6, 2021·Annals of Pediatric Endocrinology & Metabolism·Inderpal Singh Kochar, Rakhi Jain

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.