Pancreatic manifestations of von Hippel-Lindau disease-effect of imaging on clinical management

Journal of Computer Assisted Tomography
Matthew S DavenportJames H Ellis

Abstract

To assess the impact of imaging on pancreatic lesion management in von Hippel-Lindau disease (VHL). We reviewed sequential computed tomography (CT) and magnetic resonance examinations (1997-2008) of 33 patients with VHL who had at least 1 pancreatic lesion. One hundred sixty-seven imaging studies demonstrated innumerable simple pancreatic cysts and 58 complex pancreatic masses: 24 were complex cystic and 34 were solid (30 small [<or=2 cm] and 4 large [>2 cm]). Aggregate annual growth was significant in complex cystic and solid masses (mean, 0.39 cm/y [P = 0.006] and 0.14 cm/y [P = 0.045]). Solid mass growth differed by size (small: 0.06 cm/y [range, -0.09 to 0.31 cm/y]; large: 1.28 cm/y [range, 0-1.98 cm/y]). Thirteen masses were excised. No patient developed metastases. Arterial-phase CT improved (P = 0.0003) solid mass detection, but 28% of studies still underreported the total number. Most pancreatic masses in VHL do not require annual surveillance. Arterial-phase CT improves mass detection, but many masses remain prospectively missed.

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Citations

Jun 1, 2012·Nuclear Medicine and Molecular Imaging·Jong-Ryool OhRichard P Baum
May 12, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jonathan R DillmanAlexander J Towbin
Jun 13, 2012·Internal Medicine·Noritoshi KobayashiKensuke Kubota
Jan 23, 2015·Archives of Pathology & Laboratory Medicine·Clarissa Cassol, Ozgur Mete
Jul 12, 2011·Current Opinion in Gastroenterology·Cyrus Piraka, James M Scheiman

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