Pancreatic nerve stimulation releases neuropeptide Y- but not galanin- or calcitonin gene-related peptide-like immunoreactivity from the pig pancreas.

Journal of the Autonomic Nervous System
B AhrénR Ekman

Abstract

We investigated the possible release of galanin-, calcitonin gene-related peptide (CGRP)-, and neuropeptide Y (NPY)-like immunoreactivity from the pancreatic nerves in thiopental-anaesthetized pigs. Ten minutes stimulation of the mixed autonomic pancreatic nerves during infusion of atropine (8 or 40 Hz, 5 ms, 10 mA, n = 5) inhibited insulin secretion, during both normoglycemia (9.1 +/- 0.2 mmol/l) and hyperglycemia (28.1 +/- 0.4 mmol/l). Concomitantly, pancreatic venous concentrations of NPY-like immunoreactivity increased. For example during normoglycemia, a nerve stimulation by 8 Hz increased the pancreatic venous levels of NPY-like immunoreactivity from 294 +/- 26 pmol/l to 391 +/- 23 pmol/l (P less than 0.001). In contrast, the pancreatic venous concentrations of galanin- or CGRP-like immunoreactivity did not change during the nerve stimulation. We conclude that electrical pancreatic nerve stimulation in the pig releases NPY-like immunoreactivity without affecting the pancreatic venous concentrations of galanin- or CGRP-like immunoreactivity.

References

Mar 1, 1987·Acta Physiologica Scandinavica·S Lindskog, B Ahrén
Aug 1, 1987·Endocrinology·T GrunditzR Uddman
Sep 1, 1987·Regulatory Peptides·B E DunningG J Taborsky
Oct 1, 1988·Regulatory Peptides·M Pettersson, B Ahrén
Jan 1, 1973·The Journal of Clinical Investigation·D PorteJ Posternak

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Citations

May 12, 1993·European Journal of Pharmacology·G SkoglundM M Loubatières-Mariani
Jan 1, 1992·Progress in Neurobiology·Y DumontR Quirion
Oct 1, 1993·Acta Physiologica Scandinavica·B E Dunning, B Ahrén
Jun 1, 1992·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·B Ahrén, S Lindskog
Oct 1, 1991·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·T MessellJ J Holst
Jan 1, 1990·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·B Ahrén, M Pettersson

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