Pancreatic Neuroendocrine Tumor Presenting as Acute Pancreatitis

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Minjeong KimSeong Whi Cho

Abstract

We report a case of acute pancreatitis secondary to pancreatic neuroendocrine tumor. A 46-year old man presented with upper abdominal pain. The serum amylase and lipase were elevated. Abdominal computed tomography (CT) and magnetic resonance cholangiopancreatography revealed a 1.7 cm sized mass at the pancreas body with a dilatation of the upstream pancreatic duct and mild infiltrations of peripancreatic fat. An endoscopic ultrasound-guided fine needle biopsy was performed for the pancreatic mass, but only necrotic tissue was observed on the pathologic examination. A chest and neck CT scan revealed anterior mediastinal, paratracheal, and cervical lymph node enlargement, which were indicative of metastasis. An ultrasound-guided core needle biopsy was performed for the enlarged neck lymph node, and pathologic examination revealed a metastatic poorly differentiated carcinoma. Immunohistochemical analysis showed positive staining for synaptophysin, chromogranin A, and CD 56, indicative of a neuroendocrine carcinoma.

References

Jul 1, 1991·Digestive Diseases and Sciences·W KimuraY Morioka
Jul 20, 2010·Gastroenterology·Sung Soo AhnDokyung Kim
Aug 25, 2011·AJR. American Journal of Roentgenology·Satomi KawamotoStanley S Siegelman
Mar 15, 2012·Pancreas·Marta Tejedor BravoMaría de Los Ángeles Martín Scapa
May 23, 2014·PloS One·Wojciech BłogowskiTeresa Starzyńska
Mar 30, 2016·Critical Reviews in Oncology/hematology·A ViúdezN Ramírez

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