Pancreatic neuroendocrine tumors containing areas of iso- or hypoattenuation in dynamic contrast-enhanced computed tomography: Spectrum of imaging findings and pathological grading

European Journal of Radiology
Ryota HyodoShinji Naganawa

Abstract

To evaluate dynamic contrast-enhanced computed tomography (CT) features of pancreatic neuroendocrine tumors (PNETs) containing areas of iso- or hypoattenuation and the relationship with pathological grading. Between June 2006 and March 2014, 61 PNETs in 58 consecutive patients (29 male, 29 female; median-age 55 years), which were surgically diagnosed, underwent preoperative dynamic contrast-enhanced CT. PNETs were classified based on contrast enhancement patterns in the pancreatic phase: iso/hypo-PNETs were defined as tumors containing areas of iso- or hypoattenuation except for cystic components, and hyper-PNETs were tumors showing hyperattenuation over the whole area. CT findings and contrast-enhancement patterns of the tumors were evaluated retrospectively by two radiologists and compared with the pathological grading. Iso/hypo-PNETs comprised 26 tumors, and hyper-PNETs comprised 35 tumors. Not only hyper-PNETs but also most iso/hypo-PNETs showed peak enhancement in the pancreatic phase and a washout from the portal venous phase to the delayed phase. Iso/hypo-PNETs showed larger tumor size than the hyper-PNETs (mean, 3.7 cm vs. 1.6 cm; P<0.001), and were significantly correlated with unclear tumor margins (n=4 vs. n=0; P=0.0...Continue Reading

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Citations

Jul 6, 2018·Expert Review of Anticancer Therapy·Lingaku LeeRobert T Jensen
Jan 28, 2017·World Journal of Gastroenterology : WJG·Riccardo De RobertisMirko D'Onofrio
Aug 17, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Lokesh KhannaVenkata S Katabathina
Dec 8, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Woo Hyun PaikJae Hee Cho
Nov 17, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Yamin WanJianbo Gao

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