Pancreatic panniculitis: the "bright" side of the moon in solid cancer patients

BMC Gastroenterology
Elena GuanziroliAngelo Valerio Marzano

Abstract

Pancreatic panniculitis is a rare complication of pancreas disorders occurring in 0.3-3% of patients, most often accompanied by the pancreatic acinar carcinoma. It presents multiple, painful, deep, ill-defined, red-brown, migratory nodules and plaques of hard elastic consistency; often ulcerated and typically located on the lower proximal and distal extremities. The pathogenesis is not fully understood, but it is thought to result from lipolysis and fat necrosis with secondary tissue inflammation induced by pancreatic enzymes. Histopathology shows subcutaneous lobular fat necrosis with anuclear adipocytes (called ghost cells) surrounded by a mixed inflammatory infiltrate. Focal calcification may also be seen. The treatment is directed to the underlying disorder, which may result in regression of skin lesions. We present two cases of pancreatic panniculitis with similar clinical, laboratory, and histopathological features associated with different internal malignancy. The first case, after extensive investigations showed the presence of a pancreatic carcinoma with multiple liver metastases and a poor prognosis. The second one instead is the first case in literature where painful subcutaneous nodules of the legs were the early ma...Continue Reading

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Citations

Sep 29, 2020·Critical Reviews in Food Science and Nutrition·Ilkem Demirkesen, Berrin Ozkaya
Dec 21, 2018·World Journal of Clinical Cases·Meng-Yu Zhang, Bo-Le Tian
May 14, 2019·Journal of Cutaneous Pathology·Amrita GoyalElie Gertner
Aug 19, 2020·Journal of Clinical Medicine·Raluca MiulescuMariana Jinga
Oct 12, 2020·International Journal of Dermatology·Eran ShavitAfsaneh Alavi
Dec 5, 2021·Clinical Journal of Gastroenterology·Sunil KumarAwanish Kumar

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Methods Mentioned

BETA
biopsy

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