Pancreatic pathology in type 1 diabetes mellitus

Endocrine Pathology
Sarah J RichardsonAlan K Foulis


Type 1 diabetes is a multifactorial disease resulting from a complex interplay between host genetics, the immune system and the environment, that culminates in the destruction of insulin-producing beta cells. The incidence of type 1 diabetes is increasing at an alarming rate, especially in children under the age of 5 (Gepts in Diabetes 14(10):619-613, 1965; Foulis et al. in Lancet 29(5):267-274, 1986; Gamble, Taylor and Cumming in British Medical Journal 4(5887):260-262 1973). Genetic predisposition, although clearly important, cannot explain this rise, and so, it has been proposed that changes in the 'environment' and/or changes in 'how we respond to our environment' must contribute to this rising incidence. In order to gain an improved understanding of the factors influencing the disease process, it is important, firstly, to focus on the organ at the centre of the illness-the pancreas. This review summarises our knowledge of the pathology of the endocrine pancreas in human type 1 diabetes and, in particular, explores the progression of this understanding over the past 25 years.


May 24, 1979·The New England Journal of Medicine·J W YoonA L Notkins
Jun 1, 1991·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S R ShiK L Kalra
Aug 1, 1974·Diabetes·A C MacCuishW J Irvine
Nov 3, 1973·British Medical Journal·D R GambleH Cumming
Feb 26, 2003·Journal of Medical Virology·Anja PaananenMerja Roivainen
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Malin Flodström-TullbergNora Sarvetnick
Apr 4, 2006·Trends in Endocrinology and Metabolism : TEM·Pablo A Silveira, Shane T Grey
Dec 13, 2006·Microbiology and Molecular Biology Reviews : MMBR·M A GarcíaM Esteban
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Francesco DottaPiero Marchetti
Jun 15, 2007·Diabetes·Peter In't VeldDaniel Pipeleers
Sep 18, 2007·Journal of Clinical Pathology·J K S Chia, A Y Chia
Jan 9, 2009·Clinical and Experimental Immunology·A WillcoxN G Morgan
Aug 4, 2009·Journal of Clinical Pathology·A Y Chia, J K Chia
Jan 12, 2010·Clinical and Experimental Immunology·B O RoepF Dotta
Jan 26, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Maarit OikarinenHeikki Hyöty
Apr 29, 2010·Seminars in Immunopathology·Sarah J RichardsonAlan K Foulis
Aug 24, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Sarah J RichardsonNoel G Morgan
Oct 15, 2010·Diabetes·Sami OikarinenHeikki Hyöty

❮ Previous
Next ❯


Aug 19, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Oskar SkogOlle Korsgren
Sep 2, 2014·Trends in Endocrinology and Metabolism : TEM·Noel G Morgan, Sarah J Richardson
Oct 3, 2015·Expert Opinion on Therapeutic Targets·Dass S Vinay, Byoung S Kwon
Dec 4, 2015·Autoimmunity Reviews·Concetta Ferretti, Antonio La Cava
Sep 24, 2015·Journal of Applied Toxicology : JAT·Ştefana BâliciHorea Matei
Dec 10, 2015·Drugs·Johnny Ludvigsson
Dec 17, 2014·IUBMB Life·Noel G MorganSarah J Richardson
Mar 30, 2016·Nature Reviews. Endocrinology·Anne Op de Beeck, Decio L Eizirik
Jan 9, 2015·Annals of Medicine and Surgery·Sergei V Jargin
Sep 8, 2015·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Ştefana BâliciHorea Matei
Apr 14, 2016·Journal of Autoimmunity·Mario R Ehlers
Oct 18, 2014·Islets·M A Russell, N G Morgan
Apr 25, 2015·Diabetes·Teresa Rodriguez-Calvo, Matthias G von Herrath
Feb 18, 2015·Nature Reviews. Endocrinology·Paolo PozzilliRaffaella Buzzetti
Jun 7, 2019·Cellular and Molecular Life Sciences : CMLS·Magloire Pandoua NekouaDidier Hober
Dec 19, 2019·Diabetes/metabolism Research and Reviews·Laura NigiGuido Sebastiani
May 28, 2019·European Cardiology·Sotirios TsalamandrisDimitris Tousoulis
Aug 18, 2020·The Journal of Pharmacy and Pharmacology·Hongyu XiaoJian Liang
Jan 26, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Natasha QaisarJennifer P Wang
Jul 12, 2017·Scientific Reports·Angelo GenoniAntonio Toniolo
Jan 14, 2017·Frontiers in Physiology·Kyle C A WedgwoodKrasimira Tsaneva-Atanasova
Dec 25, 2015·Pathology International·Mutsuki MakinoKenji Kawaguchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Related Papers

Advances in Experimental Medicine and Biology
Christopher TingJamil Azzi
Expert Opinion on Therapeutic Targets
Jayne L ChamberlainLucy Sk Walker
British Medical Bulletin
Kay L Mehers, Kathleen M Gillespie
© 2021 Meta ULC. All rights reserved