Pancreatic phospholipase A2 contributes to lung injury in experimental meconium aspiration

Pediatric Research
Tomi SippolaP Kääpä

Abstract

To investigate the role of pancreatic (group I) secretory PLA2 (sPLA2-I) in the pathogenesis of meconium aspiration syndrome, human particulate meconium or its supernatant either before or after extraction of PLA2-I was insufflated into rat lungs. In addition, the pulmonary effects of intra-tracheal human and bovine PLA2-I were studied. Lungs with saline instillation served as controls. Intrapulmonary particulate meconium (both before and after PLA2-I extraction), unlike meconium supernatant, resulted in markedly elevated lung tissue PLA2 catalytic activity and human PLA2-I concentrations when compared with controls. On the other hand, tissue concentrations of the group II PLA2 remained unchanged in all meconium lungs. Pulmonary PLA2-I concentrations further correlated positively with lung injury scores. Instillation of meconium-derived human PLA2-I, at a concentration of one-third of that in particulate meconium, did not raise PLA2 activity or concentrations of PLA2-I or PLA2-II in the lung tissue from the control level, but still resulted in significantly elevated lung wet/dry ratio and injury score. In contrast, insufflation of bovine pancreatic PLA2 increased the lung tissue enzyme activity and wet/dry ratio from the contro...Continue Reading

References

May 27, 1992·European Journal of Pharmacology·C D SommersD W Snyder
Jul 1, 1991·Journal of Applied Physiology·B A HolmG Enhorning
Jan 23, 1989·Biochimica Et Biophysica Acta·T SakataM Okamoto
Jan 1, 1989·Journal of Applied Physiology·D E NiewoehnerD Wangensteen
Apr 1, 1986·British Heart Journal·P G AgostoniM D Guazzi
Aug 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·S Lloret, J J Moreno
Jun 2, 1997·Biochimica Et Biophysica Acta·S K HanW Cho
Jun 15, 1999·Molecular Medicine Today·L Touqui, L Arbibe
Mar 7, 2001·Journal of Critical Care·Y TeraoK Sumikawa
Jan 1, 2003·Biochemical and Biophysical Research Communications·Grietje Ch BeckMarietta Kaszkin
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francescopaolo GranataMassimo Triggiani

❮ Previous
Next ❯

Citations

Mar 31, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Daniele De LucaMarco Piastra
Nov 10, 2011·BMC Pediatrics·Daniele De LucaUNKNOWN Study group on Secretory Phospholipase in Paediatrics (SSPP)
May 14, 2011·Intensive Care Medicine·Daniele De LucaEttore Capoluongo
Oct 13, 2009·Early Human Development·Pekka O Kääpä
Sep 26, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroTinnakorn Chaiworapongsa
Jul 7, 2009·Biochimica Et Biophysica Acta·Eirini KitsiouliMarilena E Lekka
Dec 17, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·P Kääpä, H Soukka
Apr 30, 2020·American Journal of Respiratory Cell and Molecular Biology·Chiara AutilioDaniele De Luca

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Perinatology : Official Journal of the California Perinatal Association
P Kääpä, H Soukka
Journal of Perinatology : Official Journal of the California Perinatal Association
D Vidyasagar, A Zagariya
Journal of Perinatology : Official Journal of the California Perinatal Association
Tom E MollnesOla D Saugstad
© 2022 Meta ULC. All rights reserved