Pancreatic polypeptide response to a mixed meal is blunted in pancreatic head cancer associated with diabetes mellitus

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Phil A HartSuresh T Chari

Abstract

Pancreatic polypeptide (PP) is a hormone secreted by islet cells of the ventral pancreas. It has been proposed that a blunted PP response to a mixed meal can distinguish diabetes mellitus (DM) secondary to pancreatic disease from other types of DM. We performed a proof of concept study to determine if PP response to a mixed meal discriminates DM secondary to pancreatic cancer (PaCDM) from type 2 DM (T2DM). We studied 18 subjects with new onset DM (PaCDM (n = 9) and T2DM (n = 9); matched for age and gender). Serum PP levels were measured at 0, 30, and 60 min following a mixed meal. Increases in PP levels from baseline were compared using the Wilcoxon test. In PaCDM the PP increase following a mixed meal was less than T2DM at 30 min (median 60.0%, IQR, 33.0-119.8 vs. 134.5%, IQR, 117.5-265.9; p = 0.03), but statistically similar at 60 min (median 55.8%, interquartile range (IQR) 23.7-121.5 vs. 100.0%, IQR, 47.7-202.5; p = 0.17). In PaCDM subjects, the PP increase over baseline was smaller in those with a tumor located in the pancreatic head (n = 6) compared to the body/tail (n = 3) at 30 min (41.3% vs. 158.7%, p = 0.02) and at 60 min (37.4% vs. 167.4%,p = 0.04). Subjects with PaCDM have a blunted PP response to a mixed meal compa...Continue Reading

References

Dec 1, 1976·Gut·T E AdrianA J Barnes
Aug 9, 2005·Gastroenterology·Suresh T ChariGloria M Petersen
Apr 9, 2008·Gastroenterology·Rahul PannalaSuresh T Chari
Dec 30, 2008·The Lancet Oncology·Rahul PannalaSuresh T Chari
Jul 16, 2011·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Yunfeng Cui, Dana K Andersen
Nov 29, 2011·Diabetes/metabolism Research and Reviews·N EwaldP D Hardt
Jan 4, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Mar 27, 2013·Nature Reviews. Gastroenterology & Hepatology·Raghuwansh P SahSuresh T Chari
Jul 31, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Michael R RickelsUNKNOWN PancreasFest Recommendation Conference Participants
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Nov 29, 2015·Hematology/oncology Clinics of North America·Aaron I Vinik, Celine Chaya
Mar 9, 2017·Nutrients·Taylor M GillilandGeorge Van Buren
May 5, 2017·European Journal of Gastroenterology & Hepatology·Přemysl FričMiroslav Zavoral
Jul 10, 2019·Expert Review of Anticancer Therapy·Margherita PizzatoCarlo La Vecchia
Aug 24, 2019·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Min Kyu Jung
May 17, 2017·Diabetes·Dana K AndersenJames L Abbruzzese
Dec 21, 2018·Journal of Experimental & Clinical Cancer Research : CR·Ramesh PothurajuSurinder K Batra
Nov 14, 2019·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Marvi TariqJuan M Sarmiento
Jan 17, 2021·The Journal of Surgical Research·Bo Hyung YoonJordan M Winter
Feb 15, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Savio G BarretoDamien J Keating
Jul 16, 2021·Current Opinion in Gastroenterology·Phil A HartMark O Goodarzi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved