Pancreatic protective and hypoglycemic effects of Vitex agnus-castus L. fruit hydroalcoholic extract in D-galactose-induced aging mouse model

Research in Pharmaceutical Sciences
Akram AhangarpourSeyedeh Asma Najimi

Abstract

D-galactose induces pancreatic disorder along with aging mouse model. Vitex agnus-castus (VAC) has potential pancreatic protective effect. Hence, this study was designed to evaluate the hypoglycemic and pancreas protective effects of VAC hydroalcoholic extract in D-galactose-induced aging female mice. In the present experimental study, 72 adult female Naval Medical Research Institute (NMRI) mice (weighing 30-35 g) were divided into 6 groups of control, VAC hydroalcoholic extract, D-galactose, D-galactose + VAC hydroalcoholic extract, aged, aged + VAC hydroalcoholic extract. The aged model was prepared by subcutaneous injection of D-galactose for 45 days and, VAC hydroalcoholic extract was gavaged twice a day in the last 7 days. 24 h after the last drug and extract administrations, serum samples and pancreatic tissues were removed to evaluate experimental and histological determinations. Serum glucose level decreased in VAC, D-galactose and, aged-treated groups compared to the control (P < 0.05). Insulin level increased in VAC and decreased in D-galactose and aged VAC-treated mice compared to the control (P < 0.05). Homeostasis model assessment-estimated insulin resistance (HOMA-IR) increased in D-galactose, aging, and VAC hydro...Continue Reading

Citations

Jan 13, 2018·Pathobiology of Aging & Age Related Diseases·Akram AhangarpourMohammad Badavi
Feb 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alaa M Abu-Odeh, Wamidh H Talib
Aug 3, 2021·BioMed Research International·Assia BerraniRachid Bengueddour
Sep 30, 2020·Current Pharmaceutical Design·Kondeti R ShanmugamKesireddy S Reddy

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