PMID: 22363992Mar 1, 2012Paper

Pancreatic secretory trypsin inhibitor gene N34S mutation in patients with idiopathic chronic pancreatitis

Ėksperimental'nai︠a︡ i klinicheskai︠a︡ gastroėnterologii︠a︡ = Experimental & clinical gastroenterology
Iu A KucheriavyĭI V Maev

Abstract

To determine the frequency and prognostic significance of mutation N34S in the development of CP in a mixed Russian population. The study included 83 patients with idiopathic CP and 103 healthy individuals. The diagnosis of CP was based on clinical and instrumental data in accordance with the criteria of M-ANNHEIM. Everyone involved in this study using PCR followed by restriction analysis performed the N34S mutation analysis in the gene for the ICU. N34S mutation was detected in 12 patients with CP and in 3 of the control group, which accounted for 14.6 and 2.9% respectively; p<0,05. The odds ratio (OR) of idiopathic CP in the presence of mutation N34S was 4.62 (95% confidence interval (CI): 1,21-18,37). The difference in frequency of homozygotes the mutant allele was statistically significant: 10.97 and 0.97% in the main and control groups, respectively; p<0,05. The presence of mutations did not affect the frequency and severity of functional disorders of the pancreas, but the mutation N34S was statistically significantly more common in patients with calcifying pancreatitis (p<0,01) and the presence of pseudocysts (p<0,05). OR the development of calcification in patients with the presence of N345 was 13.44 (95% CI: 6,29-23,78)...Continue Reading

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