PMID: 6105026Jun 1, 1980Paper

Pancreatic somatostatinoma presenting with hypoglycaemia

Clinical Endocrinology
J WrightV Marks

Abstract

A 33-year-old woman with a 2 month history of vague ill health was admitted to hospital in hypoglycaemic coma. Preoperative investigation suggested malignant insulinoma as the probable cause of illness, but immunohistological examination of the tumour showed it to consist mainly of somatostatin-containing cells but sparse insulin-secreting cells were also present. Plasma immunoreactive somatostatin levels were from fifty to 200 times the upper limit of normal and rose in response to arginine and fell during diazoxide infusion. The hypoglycaemia was unusually sensitive to the hyperglycaemic effects of diazoxide and chlorothiazide and, with 5-fluorouracil as the only specific anti-tumour agent, there has been clinical, biochemical and radiological evidence of tumour regression.

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Citations

Jun 1, 1991·Diabetes/metabolism Reviews·V Marks, J D Teale
Apr 1, 1990·Journal of Surgical Oncology·K KonomiK Yamaguchi
Dec 22, 1983·The New England Journal of Medicine·S Reichlin
Jan 1, 1983·Acta Pathologica Japonica·H KanekoH Nitta
Dec 4, 1982·British Medical Journal·A M CantorD Mangion
Jan 25, 2014·European Journal of Endocrinology·Pedro Iglesias, Juan J Díez
Jul 15, 1983·Klinische Wochenschrift·V SchusdziarraE F Pfeiffer
Nov 1, 1983·Clinics in Endocrinology and Metabolism·J A Wass
Dec 1, 1980·Clinical Endocrinology·E PenmanL H Rees
Oct 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R E BluhmK F Badr
Feb 1, 1984·Cancer·Z D GoodmanD M Lundblad
Mar 1, 1989·The British Journal of Surgery·J C ArnoldR Williams
Dec 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·R B Tattersall
Sep 1, 1987·Journal of Surgical Oncology·G J HarrisA B Cruz
Mar 8, 1986·British Medical Journal·S PrammingC Binder
Aug 10, 1985·British Medical Journal·S PrammingC Binder
Oct 9, 2019·Endocrinology, Diabetes & Metabolism·Peter WiesliChristoph Schmid

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