Pancreatic Steatosis Is Associated With Impaired Exocrine Pancreatic Function

Investigative Radiology
Marie-Luise KromreyJens-Peter Kühn

Abstract

The aim of this study was to investigate if pancreatic steatosis measured by proton density fat fraction (PDFF) is associated with exocrine pancreatic function defined by fecal elastase concentrations. A total of 1458 volunteers (777 women; age range, 21-88 years) underwent magnetic resonance imaging of the pancreas, and organ fat content was quantified by using confounder corrected PDFF. Exocrine pancreatic function was categorized by fecal elastase levels using defined cutoffs: greater than 200 μg/g normal function (n = 1319) and 200 μg/g or less impaired function (n = 139). Statistical analysis to correlate pancreatic fat content with fecal elastase included linear regression, and analyses were adjusted for known confounders for pancreatic steatosis, such as age, sex, and body mass index. Overall mean (±standard deviation) of pancreatic fat content was 7.50% ± 3.78%. Pancreatic fat content was significantly higher in subjects with impaired pancreatic exocrine function (9.36% ± 4.95%) compared with subjects with normal function (7.30% ± 3.59%; P < 0.01). Linear regression analyses showed an inverse correlation between pancreatic fat and fecal elastase levels over the whole study population (beta, -7.19 [standard error, 1.39];...Continue Reading

References

Feb 4, 1999·AJR. American Journal of Roentgenology·D S KatzM J Lane
Oct 9, 2001·Scandinavian Journal of Gastroenterology·S LüthM V Singer
Sep 20, 2007·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Y SaishoP C Butler
Oct 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Huanzhou YuScott B Reeder
Apr 17, 2009·World Journal of Gastroenterology : WJG·Jun Seok LeeYong Soo Kim
Jun 10, 2009·Pancreas·Mohammad Al-HaddadMassimo Raimondo
Feb 20, 2010·International Journal of Epidemiology·Henry VölzkeWolfgang Hoffmann
Apr 27, 2010·World Journal of Gastroenterology : WJG·Paul E SijensRonald P Stolk
Jul 31, 2010·NMR in Biomedicine·Hans-Peter MüllerJan Kassubek
Sep 8, 2010·World Journal of Gastroenterology : WJG·Cheol Woong ChoiSuk Kim
Nov 26, 2010·Magnetic Resonance Imaging Clinics of North America·Scott B Reeder, Claude B Sirlin
Jun 2, 2011·Nature Reviews. Gastroenterology & Hepatology·John S LeedsDavid S Sanders
Jun 23, 2011·Journal of Pediatric Gastroenterology and Nutrition·Els Van de VijverGigi Veereman-Wauters
Sep 20, 2011·Journal of Magnetic Resonance Imaging : JMRI·Scott B ReederClaude B Sirlin
Jul 11, 2012·Journal of Magnetic Resonance Imaging : JMRI·Scott B ReederClaude B Sirlin
May 15, 2013·PloS One·Horng-Yih OuChih-Jen Chang
Jul 28, 2016·PloS One·Frank Ulrich WeissMarkus M Lerch
Oct 1, 2016·Journal of Gastrointestinal and Liver Diseases : JGLD·Jennifer A CampbellAndrew D Hopper
Nov 24, 2016·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Sudipta Dhar ChowdhuryK A Balasubramaniam
Feb 12, 2017·BMC Medicine·Maarten R StruyvenbergSteven D Freedman

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Citations

Aug 11, 2020·Current Opinion in Pediatrics·Zachary M Sellers
Jun 22, 2021·Clinical and Experimental Gastroenterology·Celal UlasogluArda Yavuz

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