Pancreatic stone protein predicts postoperative infection in cardiac surgery patients irrespective of cardiopulmonary bypass or surgical technique

PloS One
Holger J KleinRolf Graf

Abstract

We investigated the role of pancreatic stone protein (PSP) in predicting the occurrence of infection in the postoperative course of cardiac surgery patients. Several biomarkers indicating the presence of inflammation and infection are available in the clinical routine; yet, their utility in the postoperative course of patients following cardiac surgery remains uncertain. Moreover, cardiopulmonary bypass, also referred to as "on-pump surgery", increases the susceptibility to an exaggerated inflammatory state. However, the impact of such extracorporeal circulation on circulating PSP levels remains poorly understood. In a prospective cohort of unselected patients undergoing cardiac surgery, we set out to elucidate the diagnostic accuracy of serum PSP levels as opposed to canonical biomarkers (CRP, WBC) of inflammation to discriminate between the presence of infection and surgical trauma,. In addition, we investigated whether the biomarkers were influenced by the surgical technique employed, i.e. on-pump vs. off-pump and minimally invasive surgery vs. sternotomy. Levels of circulating PSP and routine inflammatory biomarkers (CRP, WBC) were measured in samples taken from 120 patients at baseline as well as at postoperative day 1-3. ...Continue Reading

References

Apr 27, 1979·Biochemical and Biophysical Research Communications·A De CaroH Sarles
Sep 1, 1992·Differentiation; Research in Biological Diversity·J CarrèreO Guy-Crotte
Jun 1, 1996·The Annals of Thoracic Surgery·J CremerH G Borst
Jan 10, 2003·The New England Journal of Medicine·Richard S Hotchkiss, Irene E Karl
Feb 1, 2003·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J H HolmesR A Hall
Mar 29, 2003·Intensive Care Medicine·Mitchell M LevyUNKNOWN International Sepsis Definitions Conference
Apr 18, 2003·The New England Journal of Medicine·Greg S MartinMarc Moss
Apr 12, 2005·The Journal of Thoracic and Cardiovascular Surgery·Roland ProndzinskyKarl Werdan
Feb 11, 2010·Critical Care : the Official Journal of the Critical Care Forum·Charalampos Pierrakos, Jean-Louis Vincent
Nov 23, 2010·Nature Reviews. Immunology·Grace Y Chen, Gabriel Nuñez
Jul 4, 2012·Critical Care : the Official Journal of the Critical Care Forum·Yok-Ai QuePhilippe Eggimann
Aug 4, 2012·Critical Care : the Official Journal of the Critical Care Forum·Stefano Busani, Massimo Girardis
Feb 13, 2013·Critical Care Medicine·Raphael GukasjanRolf Graf
Mar 28, 2013·Critical Care : the Official Journal of the Critical Care Forum·Martin J LlewelynJonathan Cohen
Nov 28, 2013·Endocrine-related Cancer·Yeon A ChoiYoung Yang

❮ Previous
Next ❯

Citations

Aug 23, 2008·American Journal of Surgery·Flavio G RochaThomas E Clancy
Jan 24, 2019·Biomarkers in Medicine·Philippe EggimannFabien Rebeaud
Jun 7, 2020·Critical Care : the Official Journal of the Critical Care Forum·Charalampos PierrakosJean-Louis Vincent
Jun 20, 2020·World Journal of Gastroenterology : WJG·Jodi-Ann EdwardsChongmin Huan
Nov 26, 2020·Advanced Healthcare Materials·Lana PapafilippouMarilena Hadjidemetriou
Nov 13, 2021·Der Anaesthesist·Johannes EhlerTobias Schürholz

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

Statistical Package for Social Sciences ,
GPOWER

Related Concepts

Related Feeds

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.