Pancreatic Transplantation: Beta Cell Replacement

Current Treatment Options in Gastroenterology
David L. Bigam, AM James Shapiro

Abstract

Diabetes is a leading cause of morbidity and mortality worldwide. Complications of diabetes including renal failure, retinopathy, neuropathy, and cardiovascular disease limit both survival and quality of life. Pancreatic transplantation can restore euglycemia thereby stabilizing or even reversing secondary complications of diabetes as well as improving quality of life particularly in patients with labile diabetes. Recent evidence also shows an improved survival in diabetic patients that undergo pancreatic transplantation when combined with a kidney transplant. Pancreatic transplantation should more properly be referred to as beta cell replacement as the field today encompasses both whole organ and islet cell transplantation. We have outlined herein the indications and contraindications to islet or whole organ pancreas transplantation and we have described periprocedure care and short- and long-term prognosis.

References

Jun 1, 1995·Annals of Surgery·A O GaberL G Britt
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Sep 22, 1998·Annals of Surgery·H W SollingerJ D Pirsch
Feb 16, 2000·Annals of Surgery·A HumarD E Sutherland
Apr 17, 2001·Annals of Surgery·D E SutherlandJ S Najarian
Sep 28, 2001·American Journal of Surgery·A HumarD E Sutherland
Mar 26, 2002·Journal of the American Society of Nephrology : JASN·Sundaram HariharanRobert J Stratta
Apr 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K Sudhakar ReddyDinesh Ranjan
Jun 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Enver AkalinJonathan S Bromberg
Jun 7, 2003·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J TrofeM F Egidi
Jun 20, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Dixon B KaufmanWilliam E Fitzsimmons
Aug 21, 2003·Transplant International : Official Journal of the European Society for Organ Transplantation·Jonathan R T LakeyA M James Shapiro
Sep 26, 2003·Transplantation·Abhinav HumarAngelika C Gruessner
Dec 6, 2003·JAMA : the Journal of the American Medical Association·Jeffrey M VenstromDavid M Harlan
Mar 31, 2004·Journal of the American College of Surgeons·Rainer W G GruessnerAngelika C Gruessner

❮ Previous
Next ❯

Citations

Mar 16, 2012·Journal of Vascular and Interventional Radiology : JVIR·Ron C GabaJose Oberholzer

❮ Previous
Next ❯

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Transplantation Proceedings
A M ShapiroJonathan R T Lakey
Proceedings of the National Academy of Sciences of the United States of America
Przemyslaw BlyszczukAnna M Wobus
© 2021 Meta ULC. All rights reserved