Pancreatic transplantation in experimental non-insulin-dependent diabetic rats

Transplantation
N EllanJ J Altman

Abstract

The effect of pancreatic transplantation on noninsulin -dependent diabetes mellitus (NIDDM) had not been evaluated in animal models. We assessed its impact by the insulin-glucose clamp study in experimental diabetic rats. NIDDM was induced in Lewis female rats by streptozocin at the age of 5 days (n5-STZ). To determine its effect on insulin sensitivity, we measured the glucose turnover rate and performed euglycemic hyperinsulinemic clamp studies, evaluating hepatic glucose production (HGP) and glucose uptake. This assessment was conducted on 5 groups of 6 female Lewis rats: 2 groups n5-STZ tested at the age of 10 and 14 weeks, respectively; 2 normal age-matched groups; and a fifth group (n5-STZ) transplanted at 10 weeks of age and tested at 14 weeks. Heterotopic pancreaticoduodenal transplantation was performed, using an end-to-side anastomosis between the donor celiac artery and portal vein to the recipient infrarenal aorta and vena cava, respectively. Pancreatic drainage was achieved by an end-to-side duodenojejunostomy. At 10 weeks of age, diabetic n5-STZ rats showed decreased body weight, hyperglycemia, moderate insulinopenia, a significantly higher basal HGP as compared with normal controls (28.5 +/- 10 vs. 10.7 +/- 4 mg/k...Continue Reading

References

Apr 1, 1972·Transplantation·S LeeM J Orloff
Jan 1, 1983·Microsurgery·J P SquiffletJ S Najarian
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Jan 1, 1983·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·S Houry, M Huguier
Nov 19, 1994·Lancet·C G GrothA Andersson

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Citations

Jun 22, 2010·Transplantation·Alp SenerStephen T Bartlett
Sep 4, 2007·The Journal of Surgical Research·Zhoobin A MoodJan Schmidt
Nov 30, 2005·Clinical Transplantation·Dilip S NathAbhinav Humar
Apr 14, 2012·The Mount Sinai Journal of Medicine, New York·Anja RichterBernd Schröppel

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