Pancreatic tumors in multiple endocrine neoplasia type 1: clinical presentation and surgical treatment

World Journal of Surgery
D GramaJ Rastad


Among 33 patients with endocrine pancreatic tumors due to multiple endocrine neoplasia type 1 (MEN-1), 19 (58%) patients had hypergastrinemia, 7 (21%) patients had hyperinsulinism, and 7 (21%) patients had clinically non-functioning lesions. At least one gross tumor was found in all patients undergoing pancreatic surgery, including those with negative localization studies prior to operation. The patients also had additional macroscopic tumors as well as numerous microadenomas, and the lesions frequently were positive for immunostaining with multiple hormones, mainly pancreatic polypeptide, insulin, glucagon, and somatostatin. Duodenal endocrine lesions were found in 4 of 5 investigated patients and stained with gastrin and somatostatin antibodies. Distal, mainly subtotal pancreatic resection, was performed in 18 patients, eventually combined with caput tumor enucleation or duodenotomy, while a few patients underwent only tumor enucleation or a Whipple procedure. The long-term outcome of operation was most favorable in patients with hyperinsulinism; only 1 patient had clinical recurrence. Patients with hypergastrinemia experienced only transitory lowering of serum gastrin values after pancreatic surgery and 47% of them had or de...Continue Reading


May 1, 1977·The American Journal of Medicine·S J MarxG D Aurbach
Aug 1, 1991·The Journal of Clinical Endocrinology and Metabolism·B SkogseidK Oberg
Mar 15, 1990·The New England Journal of Medicine·M Pipeleers-MarichalP U Heitz
Jul 1, 1988·Archives of Surgery·C S GrantC C Reading
Sep 1, 1988·The New England Journal of Medicine·B VogelsteinJ L Bos
May 1, 1985·Archives of Internal Medicine·H K GogelD M McCarthy
Feb 1, 1988·The British Journal of Surgery·L E TisellL Grimelius
Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A G Knudson
Aug 1, 1984·World Journal of Surgery·N W ThompsonT Mervak
Mar 1, 1982·American Journal of Surgery·S R Friesen
Mar 1, 1982·Missouri Medicine·J B Marshall
Jul 1, 1964·Medicine·H S BALLARDR J HARTSOCK


Sep 1, 1993·Seminars in Surgical Oncology·J L Pasieka
Jul 14, 2007·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·U Hopt, T Keck
Aug 2, 2011·Langenbeck's Archives of Surgery·Caroline L LopezD K Bartsch
Jul 6, 2004·Current Treatment Options in Oncology·Chandrajit P Raut, Jeffrey E Lee
Nov 3, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·V GutiérrezJ Alcalde
Oct 1, 1995·Trends in Endocrinology and Metabolism : TEM·D L LearoydB G Robinson
Mar 29, 2001·European Journal of Radiology·J RickeB Wiedenmann
Oct 18, 2000·Endocrinology and Metabolism Clinics of North America·R V Thakker
Aug 30, 2003·Surgical Oncology·Gerard M Doherty
Nov 5, 1999·Journal of the American College of Surgeons·P H Jordan
Jun 10, 2009·Nature Reviews. Clinical Oncology·Volker FendrichPeter Langer
Jul 29, 1998·Journal of Internal Medicine·K Oberg, B Skogseid
Nov 12, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·A FalchettiM L Brandi
Sep 1, 1995·Journal of Internal Medicine·B Skogseid, K Oberg
Mar 11, 1998·The Australian and New Zealand Journal of Surgery·C Proye
Oct 14, 2006·Annual Review of Medicine·Vipul T LakhaniS A Wells
Feb 22, 2007·Neuroendocrinology·Massimo FalconiEuropean Neuroendocrine Tumor Society
Jun 16, 2009·Internal Medicine·Saori IshigakiKazue Takano
Oct 13, 2006·Journal of Endocrinological Investigation·M Queiroz AlmeidaM A Albergaria Pereira
Oct 13, 2004·Neuroendocrinology·Göran AkerströmLiliana Osmak
May 9, 2006·World Journal of Surgery·Maria A KouvarakiNancy D Perrier
Apr 9, 2009·Expert Opinion on Pharmacotherapy·C Mel Wilcox, Basil I Hirschowitz
Oct 20, 2009·The Surgical Clinics of North America·Göran Akerström, Peter Stålberg
Aug 7, 2009·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·S L OngA R Dennison
Jan 22, 2008·Best Practice & Research. Clinical Gastroenterology·N Alexakis, J P Neoptolemos
Dec 22, 2004·Cancer·Nirupa SachithanandanJ Burgess
Feb 19, 2005·Journal of Surgical Oncology·Maria A KouvarakiDouglas B Evans
May 21, 2003·Journal of Internal Medicine·G M Doherty, N W Thompson
Jan 20, 2005·Surgery·Mark S HausmanGerard M Doherty
Dec 1, 1996·Baillière's Clinical Gastroenterology·A P GoldstoneJ A Lynn
Jul 14, 2004·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·N AlexakisJ P Neoptolemos
Jul 1, 2005·Annales d'endocrinologie·A FalchettiM L Brandi
Oct 29, 2005·Best Practice & Research. Clinical Gastroenterology·Göran AkerströmB Skogseid
Sep 27, 2005·Best Practice & Research. Clinical Gastroenterology·U Plöckinger, B Wiedenmann
Sep 14, 2015·Surgical Oncology Clinics of North America·Jeffrey A NortonRobert T Jensen
Sep 1, 2000·Seminars in Cancer Biology·F Ki WongB Tean Teh
Jun 30, 2015·International Journal of Surgery·Claudio MaurielloGiovanni Conzo
Jun 27, 1998·Journal of Pediatric Endocrinology & Metabolism : JPEM·D L LearoydB G Robinson
Feb 25, 1999·The Australian and New Zealand Journal of Surgery·C Proye, H H Nguyen
Aug 24, 2004·Oncogene·Rebecca NagyC Eng

Related Concepts

Related Feeds

Adenoma, Islet Cell

Islet Cell Adenoma arises in the islet cells, which are insulin producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Adenoma here.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.